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Brenton Cavanagh

Explore the profile of Brenton Cavanagh including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 32
Citations 448
Followers 0
Related Specialties
Biomedical Engineering
Pharmacology
Neurology
Top 10 Co-Authors
Fergal J OBrien
Sally-Ann Cryan
Rosanne M Raftery
Gang Chen
Caroline M Curtin
Irene Mencia Castano
Cathal J Kearney
Arlyng Gonzalez-Vazquez
Francesco Santarella
Ciara M Murphy
Published In
Acta Biomater
J Control Release
Front Bioeng Biotechnol
Adv Healthc Mater
Biomaterials
Affiliations
Soon will be listed here.
Recent Articles
1.
Collagen silver-doped hydroxyapatite scaffolds reinforced with 3D printed frameworks for infection prevention and enhanced repair of load-bearing bone defects
Genoud K, Sadowska J, Power R, Costard L, Ryan E, Matheson A, et al.
Biofabrication . 2025 Jan; 17(2). PMID: 39874655
Osteomyelitis, a severe bone infection, is an extremely challenging complication in the repair of traumatic bone defects. Furthermore, the use of long-term high-dose antibiotics in standard treatment increases the risks...
2.
RET overexpression leads to increased brain metastatic competency in luminal breast cancer
Jagust P, Powell A, Ola M, Watson L, de Pablos-Aragoneses A, Garcia-Gomez P, et al.
J Natl Cancer Inst . 2024 Jun; 116(10):1632-1644. PMID: 38852945
Background: Breast cancer brain metastasis is a rising occurrence, necessitating a better understanding of the mechanisms involved for effective management. Breast cancer brain metastases diverge notably from the primary tumor,...
3.
Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice
Alves M, Gil B, Villegas-Salmeron J, Salari V, Martins-Ferreira R, Arribas Blazquez M, et al.
Brain Behav Immun . 2024 May; 120:121-140. PMID: 38777288
Background: The purinergic ATP-gated P2X7 receptor (P2X7R) is increasingly recognized to contribute to pathological neuroinflammation and brain hyperexcitability. P2X7R expression has been shown to be increased in the brain, including...
4.
Microfluidics produced ATRA-loaded PLGA NPs reduced tuberculosis burden in alveolar epithelial cells and enabled high delivered dose under simulated human breathing pattern in 3D printed head models
Bahlool A, Cavanagh B, Sullivan A, MacLoughlin R, Keane J, Sullivan M, et al.
Eur J Pharm Sci . 2024 Feb; 196:106734. PMID: 38417586
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is second only to COVID-19 as the top infectious disease killer worldwide. Multi-drug resistant TB (MDR-TB) may arise because of poor patient adherence to...
5.
A Multifunctional Scaffold for Bone Infection Treatment by Delivery of microRNA Therapeutics Combined With Antimicrobial Nanoparticles
Sadowska J, Power R, Genoud K, Matheson A, Gonzalez-Vazquez A, Costard L, et al.
Adv Mater . 2023 Nov; 36(6):e2307639. PMID: 38009631
Treating bone infections and ensuring bone repair is one of the greatest global challenges of modern orthopedics, made complex by antimicrobial resistance (AMR) risks due to long-term antibiotic treatment and...
6.
Dual scaffold delivery of miR-210 mimic and miR-16 inhibitor enhances angiogenesis and osteogenesis to accelerate bone healing
Castano I, Raftery R, Chen G, Cavanagh B, Quinn B, Duffy G, et al.
Acta Biomater . 2023 Oct; 172:480-493. PMID: 37797708
Angiogenesis is critical for successful bone repair, and interestingly, miR-210 and miR-16 possess counter-active targets involved in both angiogenesis and osteogenesis: miR-210 acts as an activator by silencing EFNA3 &...
7.
Personalized Scaffolds for Diabetic Foot Ulcer Healing Using Extracellular Matrix from Induced Pluripotent Stem-Reprogrammed Patient Cells
Santarella F, Farias Correa do Amaral R, Lemoine M, Kelly D, Cavanagh B, Marinkovic M, et al.
Adv Nanobiomed Res . 2022 Dec; 2(10). PMID: 36532145
Diabetic foot ulcers (DFU) are chronic wounds sustained by pathological fibroblasts and aberrant extracellular matrix (ECM). Porous collagen-based scaffolds (CS) have shown clinical promise for treating DFUs but may benefit...
8.
Development of Inhalable ATRA-Loaded PLGA Nanoparticles as Host-Directed Immunotherapy against Tuberculosis
Bahlool A, Fattah S, OSullivan A, Cavanagh B, MacLoughlin R, Keane J, et al.
Pharmaceutics . 2022 Aug; 14(8). PMID: 36015371
Developing new effective treatment strategies to overcome the rise in multi-drug resistant tuberculosis cases (MDR-TB) represents a global challenge. A host-directed therapy (HDT), acting on the host immune response rather...
9.
Breast cancer cells mediate endothelial cell activation, promoting von Willebrand factor release, tumor adhesion, and transendothelial migration
Dhami S, Patmore S, Comerford C, Byrne C, Cavanagh B, Castle J, et al.
J Thromb Haemost . 2022 Jun; 20(10):2350-2365. PMID: 35722954
Background: Breast cancer results in a three- to four-fold increased risk of venous thromboembolism (VTE), which is associated with reduced patient survival. Despite this, the mechanisms underpinning breast cancer-associated thrombosis...
10.
Multi-factorial nerve guidance conduit engineering improves outcomes in inflammation, angiogenesis and large defect nerve repair
Hibbitts A, Koci Z, Kneafsey S, Matsiko A, Zilic L, Dervan A, et al.
Matrix Biol . 2022 Jan; 106:34-57. PMID: 35032612
Nerve guidance conduits (NGCs) are sub-optimal for long-distance injuries with inflammation and poor vascularization related to poor axonal repair. This study used a multi-factorial approach to create an optimized biomaterial...