Brent Freeman
Overview
Explore the profile of Brent Freeman including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
284
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0
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Recent Articles
1.
Onishi A, Fu Y, Patel R, Darshi M, Crespo-Masip M, Huang W, et al.
Am J Physiol Renal Physiol
. 2020 Sep;
319(4):F712-F728.
PMID: 32893663
Inhibitors of proximal tubular Na-glucose cotransporter 2 (SGLT2) are natriuretic, and they lower blood pressure. There are reports that the activities of SGLT2 and Na-H exchanger 3 (NHE3) are coordinated....
2.
Western Diet Promotes Renal Injury, Inflammation, and Fibrosis in a Murine Model of Alström Syndrome
Kim Y, Ganguly S, Nespoux J, Freeman B, Zhang H, Brenner D, et al.
Nephron
. 2020 Jul;
144(8):400-412.
PMID: 32629454
Introduction: Alström syndrome is a rare recessive genetic disease caused by mutations in ALMS1, which encodes a protein that is related to cilia function and intracellular endosome trafficking. The syndrome...
3.
Phillips N, Ke E, Nham A, Seidl M, Freeman B, Abadejos J, et al.
Front Immunol
. 2020 Jul;
11:1073.
PMID: 32625203
While B cells play a significant role in the onset of type-1 diabetes (T1D), little is know about their role in those early stages. Thus, to gain new insights into...
4.
Nespoux J, Patel R, Zhang H, Huang W, Freeman B, Sanders P, et al.
Am J Physiol Renal Physiol
. 2020 Mar;
318(5):F1100-F1112.
PMID: 32116018
In the early proximal tubule, Na-glucose cotransporter 2 (SGLT2) mediates the bulk of renal glucose reabsorption. Gene deletion in mice () was used to determine the role of SGLT2 in...
5.
Onishi A, Fu Y, Darshi M, Crespo-Masip M, Huang W, Song P, et al.
Am J Physiol Renal Physiol
. 2019 Jun;
317(2):F419-F434.
PMID: 31166707
Na/H exchanger isoform 3 (NHE3) contributes to Na/bicarbonate reabsorption and ammonium secretion in early proximal tubules. To determine its role in the diabetic kidney, type 1 diabetic Akita mice with...
6.
Song P, Huang W, Onishi A, Patel R, Kim Y, Ginkel C, et al.
Am J Physiol Renal Physiol
. 2019 May;
317(1):F207-F217.
PMID: 31091127
Na-glucose cotransporter (SGLT)1 mediates glucose reabsorption in late proximal tubules. SGLT1 also mediates macula densa (MD) sensing of an increase in luminal glucose, which increases nitric oxide (NO) synthase 1...
7.
Nespoux J, Patel R, Hudkins K, Huang W, Freeman B, Kim Y, et al.
Am J Physiol Renal Physiol
. 2019 Apr;
316(6):F1201-F1210.
PMID: 30995111
Renal Na-glucose cotransporter SGLT1 mediates glucose reabsorption in the late proximal tubule, a hypoxia-sensitive tubular segment that enters the outer medulla. Gene deletion in mice () was used to determine...
8.
Novikov A, Fu Y, Huang W, Freeman B, Patel R, Ginkel C, et al.
Am J Physiol Renal Physiol
. 2018 Nov;
316(1):F173-F185.
PMID: 30427222
Inhibitors of the Na-glucose cotransporter SGLT2 enhance urinary glucose and urate excretion and lower plasma urate levels. The mechanisms remain unclear, but a role for enhanced glucose in the tubular...
9.
Ku M, Ke E, Sabouri-Ghomi M, Abadejos J, Freeman B, Nham A, et al.
J Allergy Clin Immunol
. 2018 Jun;
142(3):997-1000.e4.
PMID: 29857010
No abstract available.
10.
Fu Y, Breljak D, Onishi A, Batz F, Patel R, Huang W, et al.
Am J Physiol Renal Physiol
. 2018 Feb;
315(2):F386-F394.
PMID: 29412698
The sodium-glucose cotransporter SGLT2 inhibitor empagliflozin (plasma protein binding ~88%) may reach its target in the brush border of the early proximal tubule by glomerular filtration and tubular secretion. Here...