Brenna S McCauley
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Explore the profile of Brenna S McCauley including associated specialties, affiliations and a list of published articles.
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11
Citations
229
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Recent Articles
1.
McCauley B, Dang W
Trends Genet
. 2023 Jul;
39(10):715-716.
PMID: 37419698
The mechanisms that underlie increased cryptic transcription during senescence and aging have been poorly understood. Sen et al. recently identified cryptic transcription start sites (cTSSs) and chromatin state changes that...
2.
McCauley B, Sun L, Yu R, Lee M, Liu H, Leeman D, et al.
Nat Aging
. 2021 Nov;
1(8):684-697.
PMID: 34746802
A repressive chromatin state featuring trimethylated lysine 36 on histone H3 (H3K36me3) and DNA methylation suppresses cryptic transcription in embryonic stem cells. Cryptic transcription is elevated with age in yeast...
3.
McCauley B, Dang W
Brief Funct Genomics
. 2021 May;
21(1):56-61.
PMID: 34050364
Cryptic transcription, the initiation of transcription from non-promoter regions within a gene body, is a type of transcriptional dysregulation that occurs throughout eukaryotes. In mammals, cryptic transcription is normally repressed...
4.
Cary G, McCauley B, Zueva O, Pattinato J, Longabaugh W, Hinman V
Nat Commun
. 2020 Dec;
11(1):6235.
PMID: 33277483
The extensive array of morphological diversity among animal taxa represents the product of millions of years of evolution. Morphology is the output of development, therefore phenotypic evolution arises from changes...
5.
Thompson J, Erkenbrack E, Hinman V, McCauley B, Petsios E, Bottjer D
Proc Natl Acad Sci U S A
. 2017 Jun;
114(23):5870-5877.
PMID: 28584090
Establishing a timeline for the evolution of novelties is a common, unifying goal at the intersection of evolutionary and developmental biology. Analyses of gene regulatory networks (GRNs) provide the ability...
6.
McCauley B, Akyar E, Saad H, Hinman V
Development
. 2014 Dec;
142(1):207-17.
PMID: 25516976
In many invertebrates, the nuclearization of β-catenin at one pole of the embryo initiates endomesoderm specification. An intriguing possibility is that a gradient of nuclear β-catenin (nβ-catenin), similar to that...
7.
McCauley B, Dang W
Biochim Biophys Acta
. 2014 May;
1839(12):1454-62.
PMID: 24859460
Aging induces myriad cellular and, ultimately, physiological changes that cause a decline in an organism's functional capabilities. Although the aging process and the pathways that regulate it have been extensively...
8.
McCauley B, Akyar E, Filliger L, Hinman V
Gene Expr Patterns
. 2013 Aug;
13(8):437-44.
PMID: 23899422
The Wnt signaling pathway is highly conserved across metazoa and has pleiotropic functions in the development of many animals. Binding of a secreted Wnt ligand to its Frizzled (Fz) receptor...
9.
McCauley B, Wright E, Exner C, Kitazawa C, Hinman V
Evodevo
. 2012 Aug;
3(1):17.
PMID: 22877149
Background: The mechanisms by which the conserved genetic "toolkit" for development generates phenotypic disparity across metazoans is poorly understood. Echinoderm larvae provide a great resource for understanding how developmental novelty...
10.
McCauley B, Weideman E, Hinman V
Dev Biol
. 2009 Nov;
340(2):200-8.
PMID: 19941847
Comparisons of orthologous developmental gene regulatory networks (GRNs) from different organisms explain how transcriptional regulation can, or cannot, change over time to cause morphological evolution and stasis. Here, we examine...