Brandon W Lewis
Overview
Explore the profile of Brandon W Lewis including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
156
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Recent Articles
1.
Britt Jr R, Ruwanpathirana A, Ford M, Lewis B
Int J Mol Sci
. 2023 Jul;
24(13).
PMID: 37445635
Asthma is a heterogenous chronic inflammatory lung disease with endotypes that manifest different immune system profiles, severity, and responses to current therapies. Regardless of endotype, asthma features increased immune cell...
2.
Ford M, Ruwanpathirana A, Lewis B, Britt Jr R
Int J Mol Sci
. 2023 Apr;
24(7).
PMID: 37047327
Asthma in elderly populations is an increasing health problem that is accompanied by diminished lung function and frequent exacerbations. As potent anti-inflammatory drugs, corticosteroids are commonly used to reduce lung...
3.
Sheikh S, Britt Jr R, Ryan-Wenger N, Khan A, Lewis B, Gushue C, et al.
Pediatr Pulmonol
. 2022 Nov;
58(3):825-833.
PMID: 36444736
Background: Cystic fibrosis (CF) is a multisystem disease with progressive deterioration. Recently, CF transmembrane conductance regulator (CFTR) modulator therapies were introduced that repair underlying protein defects. Objective of this study...
4.
Lewis B, Patial S, Saini Y
Methods Protoc
. 2022 Sep;
5(5).
PMID: 36136814
Macrophage activation refers to the enhanced functionality of macrophages in response to endogenous or exogenous stimuli. Due to the existence of limitless stimuli and a multitude of receptors on macrophage...
5.
Jackson D, Walum J, Banerjee P, Lewis B, Prakash Y, Sathish V, et al.
Respir Res
. 2022 May;
23(1):126.
PMID: 35578269
Background: Corticosteroids remain a key therapy for treating children with asthma. Patients with severe asthma are insensitive, resistant, or refractory to corticosteroids and have poorly controlled symptoms that involve airway...
6.
Lewis B, Ford M, Khan A, Walum J, Britt Jr R
Front Pharmacol
. 2022 Apr;
13:855247.
PMID: 35479312
Type 2-high severe asthma is described as a distinct endotype with Th2 inflammation, high eosinophil lung infiltration, impaired lung function, and reduced corticosteroid sensitivity. While the inflammatory milieu is similar...
7.
Lewis B, Britt Jr R
Am J Respir Cell Mol Biol
. 2022 Apr;
67(1):8-9.
PMID: 35446226
No abstract available.
8.
Lewis B, Amici S, Kim H, Shalosky E, Khan A, Walum J, et al.
J Immunol
. 2022 Mar;
208(7):1525-1533.
PMID: 35288471
Severe asthma is characterized by steroid insensitivity and poor symptom control and is responsible for most asthma-related hospital costs. Therapeutic options remain limited, in part due to limited understanding of...
9.
Lewis B, Jackson D, Amici S, Walum J, Guessas M, Guessas S, et al.
Am J Physiol Lung Cell Mol Physiol
. 2021 Nov;
321(6):L1194-L1205.
PMID: 34755542
Corticosteroid insensitivity in asthma limits the ability to effectively manage severe asthma, which is characterized by persistent airway inflammation, airway hyperresponsiveness (AHR), and airflow obstruction despite corticosteroid treatment. Recent reports...
10.
Lewis B, Ford M, Rogers L, Britt Jr R
Antioxidants (Basel)
. 2021 Sep;
10(9).
PMID: 34572965
Corticosteroid insensitivity is a key characteristic of patients with severe asthma and COPD. These individuals experience greater pulmonary oxidative stress and inflammation, which contribute to diminished lung function and frequent...