Bozitao Zhong
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Explore the profile of Bozitao Zhong including associated specialties, affiliations and a list of published articles.
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11
Citations
24
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Recent Articles
1.
Zhou B, Tan Y, Hu Y, Zheng L, Zhong B, Hong L
mLife
. 2025 Jan;
3(4):477-491.
PMID: 39744096
Advances in deep learning have significantly aided protein engineering in addressing challenges in industrial production, healthcare, and environmental sustainability. This review frames frequently researched problems in protein understanding and engineering...
2.
Cai H, Zhang Z, Wang M, Zhong B, Li Q, Zhong Y, et al.
Nat Commun
. 2024 Oct;
15(1):8675.
PMID: 39375360
No abstract available.
3.
Zhou B, Zheng L, Wu B, Yi K, Zhong B, Tan Y, et al.
Cell Discov
. 2024 Sep;
10(1):95.
PMID: 39251570
Deep learning-based methods for generating functional proteins address the growing need for novel biocatalysts, allowing for precise tailoring of functionalities to meet specific requirements. This advancement leads to the development...
4.
Cai H, Zhang Z, Wang M, Zhong B, Li Q, Zhong Y, et al.
Nat Commun
. 2024 Sep;
15(1):7785.
PMID: 39242604
Increasing the binding affinity of an antibody to its target antigen is a crucial task in antibody therapeutics development. This paper presents a pretrainable geometric graph neural network, GearBind, and...
5.
Tan Y, Li M, Zhou B, Zhong B, Zheng L, Tan P, et al.
J Chem Inf Model
. 2024 Aug;
64(16):6338-6349.
PMID: 39110130
Fine-tuning pretrained protein language models (PLMs) has emerged as a prominent strategy for enhancing downstream prediction tasks, often outperforming traditional supervised learning approaches. As a widely applied powerful technique in...
6.
Huang F, Xu X, Dong H, Li N, Zhong B, Lu H, et al.
Bioresour Bioprocess
. 2024 Apr;
9(1):57.
PMID: 38647609
Background: Prokaryotic Argonaute (pAgo) proteins are well-known oligonucleotide-directed endonucleases, which contain a conserved PIWI domain required for endonuclease activity. Distantly related to pAgos, PIWI-RE family, which is defined as PIWI...
7.
Zheng L, Zhou B, Yang Y, Zan B, Zhong B, Wu B, et al.
Chem Sci
. 2024 Apr;
15(15):5612-5626.
PMID: 38638240
Prokaryotic Argonaute (pAgo) proteins, a class of DNA/RNA-guided programmable endonucleases, have been extensively utilized in nucleic acid-based biosensors. The specific binding and cleavage of nucleic acids by pAgo proteins, which...
8.
Phosphorylation Modification Force Field FB18CMAP Improving Conformation Sampling of Phosphoproteins
Song G, Zhong B, Zhang B, Rehman A, Chen H
J Chem Inf Model
. 2023 Feb;
63(5):1602-1614.
PMID: 36800279
Phosphorylation of proteins plays an important regulatory role at almost all levels of cellular organization. Molecular dynamics (MD) simulation is a promising tool to reveal the mechanism of how phosphorylation...
9.
Zhao W, Zhong B, Zheng L, Tan P, Wang Y, Leng H, et al.
Nat Commun
. 2022 Dec;
13(1):7861.
PMID: 36543797
Ancestral metabolism has remained controversial due to a lack of evidence beyond sequence-based reconstructions. Although prebiotic chemists have provided hints that metabolism might originate from non-enzymatic protometabolic pathways, gaps between...
10.
Zhong B, Song G, Chen H
Int J Mol Sci
. 2022 Oct;
23(19).
PMID: 36232586
Phosphorylation plays a key role in plant biology, such as the accumulation of plant cells to form the observed proteome. Statistical analysis found that many phosphorylation sites are located in...