Boudewijn T H M Sleutjes
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Explore the profile of Boudewijn T H M Sleutjes including associated specialties, affiliations and a list of published articles.
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24
Citations
114
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Recent Articles
1.
Ros L, Sleutjes B, Goedee H, Asselman F, Cuppen I, van Eijk R, et al.
Muscle Nerve
. 2025 Mar;
PMID: 40028690
Introduction/aims: Survival Motor Neuron 1 (SMN1)-related spinal muscular atrophy (SMA) is characterized by α-motor neuron degeneration, with sensory function assumed to be clinically preserved. However, recent studies in severely affected...
2.
Stikvoort Garcia D, van den Berg L, Sleutjes B, Goedee H
Muscle Nerve
. 2025 Jan;
71(4):680-684.
PMID: 39834142
Introduction/aims: Reduced nerve sizes obtained by nerve ultrasound (NUS) have been proposed as a potential diagnostic marker for amyotrophic lateral sclerosis (ALS). However, prospective studies evaluating patients with suspected ALS...
3.
Stikvoort Garcia D, Goedee H, van Eijk R, van Schelven L, van den Berg L, Sleutjes B
Brain
. 2024 Apr;
147(8):2842-2853.
PMID: 38662766
Amyotrophic lateral sclerosis is a devastating neurodegenerative disease, characterized by loss of central and peripheral motor neurons. Although the disease is clinically and genetically heterogeneous, axonal hyperexcitability is a commonly...
4.
Sleutjes B, Stikvoort Garcia D, van Doorn P, Goedee H, van den Berg L
J Neural Eng
. 2023 Sep;
20(5).
PMID: 37774693
To simulate progressive motor neuron loss and collateral reinnervation in motor neuron diseases (MNDs) by developing a dynamic muscle model based on human single motor unit (MU) surface-electromyography (EMG) recordings.Single...
5.
Ros L, Sleutjes B, Stikvoort Garcia D, Goedee H, Asselman F, van den Berg L, et al.
Clin Neurophysiol Pract
. 2023 Aug;
8:123-131.
PMID: 37554725
Objective: Electrophysiological techniques are emerging as an aid in identifying prognostic or therapeutic biomarkers in patients with spinal muscular atrophy (SMA), but electrophysiological assessments may be burdensome for patients. We,...
6.
Ros L, Goedee H, Franssen H, Asselman F, Bartels B, Cuppen I, et al.
BMC Neurol
. 2023 Apr;
23(1):164.
PMID: 37095427
Background: Hereditary spinal muscular atrophy (SMA) is a motor neuron disorder with a wide range in severity in children and adults. Two therapies that alter splicing of the Survival Motor...
7.
Willemse S, Roes K, Van Damme P, Hardiman O, Ingre C, Povedano M, et al.
Trials
. 2022 Dec;
23(1):978.
PMID: 36471413
Background: Given the large genetic heterogeneity in amyotrophic lateral sclerosis (ALS), it seems likely that genetic subgroups may benefit differently from treatment. An exploratory meta-analysis identified that patients homozygous for...
8.
Sleutjes B, Stikvoort Garcia D, Kovalchuk M, Heuberger J, Groeneveld G, Franssen H, et al.
Pharmacol Res Perspect
. 2022 Jul;
10(4):e00983.
PMID: 35881020
Altered motor neuron excitability in patients with amyotrophic lateral sclerosis (ALS) has been suggested to be an early pathophysiological mechanism associated with motor neuron death. Compounds that affect membrane excitability...
9.
Stikvoort Garcia D, Kovalchuk M, Goedee H, van Schelven L, van den Berg L, Franssen H, et al.
Muscle Nerve
. 2021 Dec;
65(3):317-325.
PMID: 34854491
Introduction/aims: Progressive axonal loss in multifocal motor neuropathy (MMN) is often assessed with nerve conduction studies (NCS), by recording maximum compound muscle action potentials (CMAPs). However, reinnervation maintains the CMAP...
10.
Sleutjes B, Bystrup Jacobsen A, Tankisi H, Gorkem Sirin N, Oge A, Henderson R, et al.
Clin Neurophysiol
. 2021 Nov;
132(12):3152-3159.
PMID: 34749234
Objective: To determine which compound muscle action potential (CMAP) scan-derived electrophysiological markers are most sensitive for monitoring disease progression in amyotrophic lateral sclerosis (ALS), and whether they hold value for...