Blake Wiedenheft
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Explore the profile of Blake Wiedenheft including associated specialties, affiliations and a list of published articles.
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89
Citations
5297
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Recent Articles
11.
Adler B, Trinidad M, Bellieny-Rabelo D, Zhang E, Karp H, Skopintsev P, et al.
Nucleic Acids Res
. 2023 Oct;
52(D1):D590-D596.
PMID: 37889041
CRISPR-Cas enzymes enable RNA-guided bacterial immunity and are widely used for biotechnological applications including genome editing. In particular, the Class 2 CRISPR-associated enzymes (Cas9, Cas12 and Cas13 families), have been...
12.
Henriques W, Young J, Nemudryi A, Nemudraia A, Wiedenheft B, Malik H
bioRxiv
. 2023 Sep;
PMID: 37745568
Selfish genetic elements and their remnants comprise at least half of the human genome. Active transposons duplicate by inserting copies at new sites in a host genome. Following insertion, transposons...
13.
Santiago-Frangos A, Henriques W, Wiegand T, Gauvin C, Buyukyoruk M, Graham A, et al.
Nat Struct Mol Biol
. 2023 Sep;
30(11):1675-1685.
PMID: 37710013
Bacteria and archaea acquire resistance to viruses and plasmids by integrating fragments of foreign DNA into the first repeat of a CRISPR array. However, the mechanism of site-specific integration remains...
14.
Nemudryi A, Nemudraia A, Nichols J, Scherffius A, Zahl T, Wiedenheft B
Sci Adv
. 2023 Sep;
9(37):eadj8277.
PMID: 37703376
CRISPR RNA-guided endonucleases have enabled precise editing of DNA. However, options for editing RNA remain limited. Here, we combine sequence-specific RNA cleavage by CRISPR ribonucleases with programmable RNA repair to...
15.
Nemudraia A, Nemudryi A, Wiedenheft B
bioRxiv
. 2023 Sep;
PMID: 37693568
Genome editing with CRISPR RNA-guided endonucleases generates DNA breaks that are resolved by cellular DNA repair machinery. However, analogous methods to manipulate RNA remain unavailable. Here, we show that site-specific...
16.
Nemudryi A, Nemudraia A, Nichols J, Scherffius A, Zahl T, Wiedenheft B
bioRxiv
. 2023 Jun;
PMID: 37292641
One-sentence Summary: Programmable CRISPR RNA-guided ribonucleases enable recombinant RNA technology.
17.
Buyukyoruk M, Henriques W, Wiedenheft B
CRISPR J
. 2023 Apr;
6(3):216-221.
PMID: 37042651
Clustered regularly interspaced short palindromic repeats (CRISPRs) and their associated genes () are essential components of adaptive immune systems that protect bacteria and archaea from viral infection. CRISPR-Cas systems are...
18.
Wiegand T, Wilkinson R, Santiago-Frangos A, Lynes M, Hatzenpichler R, Wiedenheft B
CRISPR J
. 2023 Mar;
6(2):152-162.
PMID: 36912817
Cas10 proteins are large subunits of type III CRISPR RNA (crRNA)-guided surveillance complexes, many of which have nuclease and cyclase activities. Here, we use computational and phylogenetic methods to identify...
19.
de Mattos C, Faith D, Nemudryi A, Schmidt A, Bublitz D, Hammond L, et al.
Proc Natl Acad Sci U S A
. 2023 Feb;
120(9):e2216430120.
PMID: 36802441
Monitoring the extracellular environment for danger signals is a critical aspect of cellular survival. However, the danger signals released by dying bacteria and the mechanisms bacteria use for threat assessment...
20.
Nemudraia A, Nemudryi A, Buyukyoruk M, Scherffius A, Zahl T, Wiegand T, et al.
Nat Commun
. 2022 Dec;
13(1):7762.
PMID: 36522348
Type-III CRISPR-Cas systems have recently been adopted for sequence-specific detection of SARS-CoV-2. Here, we repurpose the type III-A CRISPR complex from Thermus thermophilus (TtCsm) for programmable capture and concentration of...