Binyuan Zhai
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Explore the profile of Binyuan Zhai including associated specialties, affiliations and a list of published articles.
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15
Citations
122
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Recent Articles
1.
Temperature regulates negative supercoils to modulate meiotic crossovers and chromosome organization
Tan Y, Tan T, Zhang S, Li B, Chen B, Zhou X, et al.
Sci China Life Sci
. 2024 Jul;
67(11):2426-2443.
PMID: 39048717
Crossover recombination is a hallmark of meiosis that holds the paternal and maternal chromosomes (homologs) together for their faithful segregation, while promoting genetic diversity of the progeny. The pattern of...
2.
Nie H, Kong X, Song X, Guo X, Li Z, Fan C, et al.
Biol Reprod
. 2024 Jan;
110(4):648-659.
PMID: 38224305
Histone post-translational modifications, such as phosphorylation, methylation, acetylation, and ubiquitination, play vital roles in various chromatin-based cellular processes. Meiosis is crucial for organisms that depend on sexual reproduction to produce...
3.
Dna2 removes toxic ssDNA-RPA filaments generated from meiotic recombination-associated DNA synthesis
Zhai B, Zhang S, Li B, Zhang J, Yang X, Tan Y, et al.
Nucleic Acids Res
. 2023 Jun;
51(15):7914-7935.
PMID: 37351599
During the repair of DNA double-strand breaks (DSBs), de novo synthesized DNA strands can displace the parental strand to generate single-strand DNAs (ssDNAs). Many programmed DSBs and thus many ssDNAs...
4.
Tan T, Tan Y, Wang Y, Yang X, Zhai B, Zhang S, et al.
Nucleic Acids Res
. 2022 Sep;
50(18):10418-10435.
PMID: 36107772
Interference exists ubiquitously in many biological processes. Crossover interference patterns meiotic crossovers, which are required for faithful chromosome segregation and evolutionary adaption. However, what the interference signal is and how...
5.
Yang X, Song M, Wang Y, Tan T, Tian Z, Zhai B, et al.
Proc Natl Acad Sci U S A
. 2022 Apr;
119(17):e2106902119.
PMID: 35439061
Meiotic crossover (CO) recombination is tightly regulated by chromosome architecture to ensure faithful chromosome segregation and to reshuffle alleles between parental chromosomes for genetic diversity of progeny. However, regulation of...
6.
Shang Y, Tan T, Fan C, Nie H, Wang Y, Yang X, et al.
Biol Reprod
. 2022 Feb;
107(1):275-288.
PMID: 35191959
Meiosis is the foundation of sexual reproduction, and crossover recombination is one hallmark of meiosis. Crossovers establish the physical connections between homolog chromosomes (homologs) for their proper segregation and exchange...
7.
Yang X, Zhai B, Wang S, Kong X, Tan Y, Liu L, et al.
Cell Rep
. 2021 Dec;
37(10):110097.
PMID: 34879269
RNA-DNA hybrids are often associated with genome instability and also function as a cellular regulator in many biological processes. In this study, we show that accumulated RNA-DNA hybrids cause multiple...
8.
Wang Y, Zhai B, Tan T, Yang X, Zhang J, Song M, et al.
Nucleic Acids Res
. 2021 Aug;
49(16):9353-9373.
PMID: 34417612
Meiotic recombination is integrated into and regulated by meiotic chromosomes, which is organized as loop/axis architecture. However, the regulation of chromosome organization is poorly understood. Here, we show Esa1, the...
9.
Song M, Zhai B, Yang X, Tan T, Wang Y, Yang X, et al.
Sci Adv
. 2021 Mar;
7(11).
PMID: 33712462
Meiotic chromosomes have a loop/axis architecture, with axis length determining crossover frequency. Meiosis-specific Pds5 depletion mutants have shorter chromosome axes and lower homologous chromosome pairing and recombination frequency. However, it...
10.
Wang S, Shang Y, Liu Y, Zhai B, Yang X, Zhang L
Asian J Androl
. 2021 Feb;
23(6):562-571.
PMID: 33533735
Repairing DNA double-strand breaks (DSBs) with homologous chromosomes as templates is the hallmark of meiosis. The critical outcome of meiotic homologous recombination is crossovers, which ensure faithful chromosome segregation and...