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Bigboy Simbi

Explore the profile of Bigboy Simbi including associated specialties, affiliations and a list of published articles. Areas
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Citations 11
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Recent Articles
1.
Mirczuk S, Scudder C, Read J, Crossley V, Regan J, Richardson K, et al.
Int J Mol Sci . 2021 Jan; 22(3). PMID: 33499110
Patients harbouring mutations in genes encoding C-type natriuretic peptide (CNP; ) or its receptor guanylyl cyclase B (GC-B, ) suffer from severe growth phenotypes; loss-of-function mutations cause achondroplasia, whereas gain-of-function...
2.
Day A, Jameson Z, Hyde C, Simbi B, Fowkes R, Lawson C
Biosensors (Basel) . 2018 Sep; 8(3). PMID: 30223437
Cardiovascular diseases, including atherosclerosis, now account for more deaths in the Western world than from any other cause. Atherosclerosis has a chronic inflammatory component involving Th1 pro-inflammatory cytokines such as...
3.
Thompson I, Mirczuk S, Smith L, Lessey A, Simbi B, Sunters A, et al.
Cell Tissue Res . 2013 Dec; 355(2):425-36. PMID: 24352806
The guanylyl cyclases, GC-A and GC-B, are selective receptors for atrial and C-type natriuretic peptides (ANP and CNP, respectively). In the anterior pituitary, CNP and GC-B are major regulators of...