Bharathwaj Sathyamoorthy
Overview
Explore the profile of Bharathwaj Sathyamoorthy including associated specialties, affiliations and a list of published articles.
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25
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583
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Recent Articles
1.
Jaisal M, Sannapureddi R, Ash S, Sathyamoorthy B
Chem Asian J
. 2025 Jan;
:e202401335.
PMID: 39871698
Polymerases erroneously incorporate Guanine-Thymine (dG⋅dT) mismatches in genomic DNA that further evades repair by transient sampling of tautomeric/ionic states compromising fidelity of repairing dG⋅dT mismatches. In conjunction, significant frequency of...
2.
Litberg T, Sannapureddi R, Huang Z, Son A, Sathyamoorthy B, Horowitz S
RNA Biol
. 2023 Jul;
20(1):495-509.
PMID: 37493593
Maintaining a healthy protein folding environment is essential for cellular function. Recently, we found that nucleic acids, G-quadruplexes in particular, are potent chaperones for preventing protein aggregation. With the aid...
3.
Sannapureddi R, Mohanty M, Salmon L, Sathyamoorthy B
J Am Chem Soc
. 2023 Jul;
145(28):15370-15380.
PMID: 37428641
DNA G-quadruplexes are essential motifs in molecular biology performing a wide range of functions enabled by their unique and diverse structures. In this study, we focus on the conformational plasticity...
4.
Jaisal M, Sannapureddi R, Rana A, Sathyamoorthy B
Phys Chem Chem Phys
. 2022 Dec;
25(1):241-254.
PMID: 36511891
DNA epigenetic modifications such as 5-methyl (C), 5-hydroxymethyl (C), 5-formyl (C) and 5-carboxyl (C) cytosine have unique and specific biological roles. Crystallographic studies of C containing duplexes were conducted in...
5.
Kumar S, Sannapureddi R, Todankar C, Ramanathan R, Biswas A, Sathyamoorthy B, et al.
Biochemistry
. 2022 May;
61(11):1064-1076.
PMID: 35584037
G-Quadruplex (G4) structures play a pivotal role in diverse biological functions, including essential processes, such as telomere maintenance and gene regulation. G4 structures formed in functional regions of genomes are...
6.
Mahla R, Kumar A, Tutill H, Krishnaji S, Sathyamoorthy B, Noursadeghi M, et al.
Tuberculosis (Edinb)
. 2021 Jan;
126:102046.
PMID: 33421909
RNASeq analysis of PBMCs from treatment naïve TB patients and healthy controls revealed that M. tuberculosis (Mtb) infection dysregulates several metabolic pathways and upregulates BNIP3L/NIX receptor mediated mitophagy. Analysis of...
7.
Sannapureddi R, Mohanty M, Gautam A, Sathyamoorthy B
J Phys Chem Lett
. 2020 Nov;
11(23):10016-10022.
PMID: 33179931
G-quadruplexes are nucleic acid motifs formed by stacking of guanosine-tetrad pseudoplanes. They perform varied biological roles, and their distinctive structural features enable diverse applications. High-resolution structural characterization of G-quadruplexes is...
8.
Ganser L, Lee J, Rangadurai A, Merriman D, Kelly M, Kansal A, et al.
Nat Struct Mol Biol
. 2020 May;
27(6):604.
PMID: 32376863
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
9.
Cukkemane A, Kumar P, Sathyamoorthy B
Food Res Int
. 2020 Jan;
128:108679.
PMID: 31955779
Gut microbiota have been shown to affect various cellular and host response elements such as immunological, neurological, energy, storage, etc. In recent years, this has led to rapid expansion in...
10.
Zhou H, Sathyamoorthy B, Stelling A, Xu Y, Xue Y, Pigli Y, et al.
Biochemistry
. 2019 Apr;
58(15):1963-1974.
PMID: 30950607
A( syn)-T and G( syn)-C Hoogsteen base pairs in protein-bound DNA duplexes can be difficult to resolve by X-ray crystallography due to ambiguous electron density and by nuclear magnetic resonance...