Beth E Helgeson
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Explore the profile of Beth E Helgeson including associated specialties, affiliations and a list of published articles.
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7
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1482
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Recent Articles
1.
Rhodes D, Ateeq B, Cao Q, Tomlins S, Mehra R, Laxman B, et al.
Proc Natl Acad Sci U S A
. 2009 Jun;
106(25):10284-9.
PMID: 19487683
Breast cancer patients have benefited from the use of targeted therapies directed at specific molecular alterations. To identify additional opportunities for targeted therapy, we searched for genes with marked overexpression...
2.
Tomlins S, Rhodes D, Yu J, Varambally S, Mehra R, Perner S, et al.
Cancer Cell
. 2008 Jun;
13(6):519-28.
PMID: 18538735
ETS gene fusions have been characterized in a majority of prostate cancers; however, the key molecular alterations in ETS-negative cancers are unclear. Here we used an outlier meta-analysis (meta-COPA) to...
3.
Tomlins S, Laxman B, Varambally S, Cao X, Yu J, Helgeson B, et al.
Neoplasia
. 2008 Feb;
10(2):177-88.
PMID: 18283340
TMPRSS2-ERG gene fusions are the predominant molecular subtype of prostate cancer. Here, we explored the role of TMPRSS2-ERG gene fusion product using in vitro and in vivo model systems. Transgenic...
4.
Helgeson B, Tomlins S, Shah N, Laxman B, Cao Q, Prensner J, et al.
Cancer Res
. 2008 Jan;
68(1):73-80.
PMID: 18172298
Recurrent gene fusions involving oncogenic ETS transcription factors (including ERG, ETV1, and ETV4) have been identified in a large fraction of prostate cancers. The most common fusions contain the 5'...
5.
Tomlins S, Laxman B, Dhanasekaran S, Helgeson B, Cao X, Morris D, et al.
Nature
. 2007 Aug;
448(7153):595-9.
PMID: 17671502
Recently, we identified recurrent gene fusions involving the 5' untranslated region of the androgen-regulated gene TMPRSS2 and the ETS (E26 transformation-specific) family genes ERG, ETV1 or ETV4 in most prostate...
6.
Laxman B, Tomlins S, Mehra R, Morris D, Wang L, Helgeson B, et al.
Neoplasia
. 2006 Oct;
8(10):885-8.
PMID: 17059688
We recently reported the identification of recurrent gene fusions in the majority of prostate cancers involving the 5' untranslated region of the androgen-regulated gene TMPRSS2 and the ETS family members...
7.
Tomlins S, Mehra R, Rhodes D, Smith L, Roulston D, Helgeson B, et al.
Cancer Res
. 2006 Apr;
66(7):3396-400.
PMID: 16585160
Although common in hematologic and mesenchymal malignancies, recurrent gene fusions have not been well characterized in epithelial carcinomas. Recently, using a novel bioinformatic approach, we identified recurrent gene fusions between...