Bernd Klaus
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Explore the profile of Bernd Klaus including associated specialties, affiliations and a list of published articles.
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22
Citations
995
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Recent Articles
1.
Lu J, Velten B, Klaus B, Ramm M, Huber W, Coulthard-Graf R
Elife
. 2023 Nov;
12.
PMID: 37994719
Individuals with PhDs and postdoctoral experience in the life sciences can pursue a variety of career paths. Many PhD students and postdocs aspire to a permanent research position at a...
2.
Zimon M, Huang Y, Trasta A, Halavatyi A, Liu J, Chen C, et al.
Nat Commun
. 2021 Nov;
12(1):6411.
PMID: 34741066
Complex traits are characterized by multiple genes and variants acting simultaneously on a phenotype. However, studying the contribution of individual pairs of genes to complex traits has been challenging since...
3.
Ibarra I, Hollmann N, Klaus B, Augsten S, Velten B, Hennig J, et al.
Nat Commun
. 2020 Jan;
11(1):124.
PMID: 31913281
Recent high-throughput transcription factor (TF) binding assays revealed that TF cooperativity is a widespread phenomenon. However, a global mechanistic and functional understanding of TF cooperativity is still lacking. To address...
4.
Ercan-Herbst E, Ehrig J, Schondorf D, Behrendt A, Klaus B, Gomez Ramos B, et al.
Acta Neuropathol Commun
. 2019 Dec;
7(1):192.
PMID: 31796124
Tau is a microtubule-binding protein that can receive various post-translational modifications (PTMs) including phosphorylation, methylation, acetylation, glycosylation, nitration, sumoylation and truncation. Hyperphosphorylation of tau is linked to its aggregation and...
5.
Pekowska A, Klaus B, Xiang W, Severino J, Daigle N, Klein F, et al.
Cell Syst
. 2018 Nov;
7(5):482-495.e10.
PMID: 30414923
The genome of pluripotent stem cells adopts a unique three-dimensional architecture featuring weakly condensed heterochromatin and large nucleosome-free regions. Yet, it is unknown whether structural loops and contact domains display...
6.
Zelezniak A, Vowinckel J, Capuano F, Messner C, Demichev V, Polowsky N, et al.
Cell Syst
. 2018 Sep;
7(3):269-283.e6.
PMID: 30195436
A challenge in solving the genotype-to-phenotype relationship is to predict a cell's metabolome, believed to correlate poorly with gene expression. Using comparative quantitative proteomics, we found that differential protein expression...
7.
Klaus B, Reisenauer S
F1000Res
. 2018 Aug;
5:1384.
PMID: 30101006
In this article, we walk through an end-to-end Affymetrix microarray differential expression workflow using Bioconductor packages. This workflow is directly applicable to current "Gene'' type arrays, e.g.the HuGene or MoGene...
8.
Mackmull M, Klaus B, Heinze I, Chokkalingam M, Beyer A, Russell R, et al.
Mol Syst Biol
. 2017 Dec;
13(12):962.
PMID: 29254951
Nuclear transport receptors (NTRs) recognize localization signals of cargos to facilitate their passage across the central channel of nuclear pore complexes (NPCs). About 30 different NTRs constitute different transport pathways...
9.
Zararsiz G, Goksuluk D, Klaus B, Korkmaz S, Eldem V, Karabulut E, et al.
PeerJ
. 2017 Oct;
5:e3890.
PMID: 29018623
RNA-Seq is a recent and efficient technique that uses the capabilities of next-generation sequencing technology for characterizing and quantifying transcriptomes. One important task using gene-expression data is to identify a...
10.
Havas K, Milchevskaya V, Radic K, Alladin A, Kafkia E, Garcia M, et al.
J Clin Invest
. 2017 May;
127(6):2091-2105.
PMID: 28504653
Tumor recurrence is the leading cause of breast cancer-related death. Recurrences are largely driven by cancer cells that survive therapeutic intervention. This poorly understood population is referred to as minimal...