Bernard Klein
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Explore the profile of Bernard Klein including associated specialties, affiliations and a list of published articles.
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121
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4542
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Recent Articles
11.
Jourdan M, Robert N, Cren M, Thibaut C, Duperray C, Kassambara A, et al.
PLoS One
. 2017 Jun;
12(6):e0179793.
PMID: 28636654
FCRL4 is an immunoregulatory receptor that belongs to the Fc receptor-like (FCRL) family. In healthy individuals, FCRL4 is specifically expressed by memory B cells (MBCs) localized in sub-epithelial regions of...
12.
Schoenhals M, Jourdan M, Bruyer A, Kassambara A, Klein B, Moreaux J
Cell Cycle
. 2017 May;
16(11):1104-1117.
PMID: 28463531
Plasma cells (PCs) generation occurs in hypoxic conditions in vivo, whereas the relevance of O pressure in PC differentiation remains unknown. Using our in vitro PC differentiation model, we investigated...
13.
Kassambara A, Jourdan M, Bruyer A, Robert N, Pantesco V, Elemento O, et al.
Nucleic Acids Res
. 2017 May;
45(10):5639-5652.
PMID: 28459970
MicroRNAs (miRNAs) are small noncoding RNAs that attenuate expression of their mRNA targets. Here, we developed a new method and an R package, to easily infer candidate miRNA-mRNA target interactions...
14.
Schoenhals M, Jourdan M, Seckinger A, Pantesco V, Hose D, Kassambara A, et al.
Cell Cycle
. 2016 May;
15(14):1919-28.
PMID: 27230497
A role of the transcription factor Krüppel-like factor 4 (KLF4) in the generation of mature plasma cells (PC) is unknown. Indeed, KLF4 is critical in controlling the differentiation of various...
15.
Jourdan M, Cren M, Schafer P, Robert N, Duperray C, Vincent L, et al.
Oncotarget
. 2016 Apr;
7(19):28096-111.
PMID: 27057635
Thalidomide, lenalidomide and pomalidomide have greatly improved the outcome of patients with multiple myeloma. However, their effects on plasma cells, the healthy counterpart of myeloma cells, are unknown. Here, we...
16.
Viziteu E, Kassambara A, Pasero P, Klein B, Moreaux J
Biomark Res
. 2016 Feb;
4:3.
PMID: 26877874
Background: RECQ helicase family members act as guardians of the genome to assure proper DNA metabolism in response to genotoxic stress. Hematological malignancies are characterized by genomic instability that is...
17.
Viziteu E, Grandmougin C, Goldschmidt H, Seckinger A, Hose D, Klein B, et al.
Br J Cancer
. 2016 Feb;
114(5):519-23.
PMID: 26867162
Background: Multiple myeloma (MM) is an incurable clonal plasma cell malignancy. The constitutive expression of HIF-1α in MM suggests that inhibition of HIF-1α-mediated transcription represents an interesting target in MM....
18.
Herviou L, Cavalli G, Cartron G, Klein B, Moreaux J
Oncotarget
. 2015 Oct;
7(3):2284-96.
PMID: 26497210
Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the Polycomb repressive complex 2, inhibits gene expression through methylation on lysine 27 of histone H3. EZH2 regulates normal hematopoietic...
19.
Seckinger A, Meissner T, Moreaux J, Benes V, Hillengass J, Castoldi M, et al.
Oncotarget
. 2015 Oct;
6(36):39165-83.
PMID: 26472281
Purpose: microRNAs regulate gene-expression in biological and pathophysiological processes, including multiple myeloma. Here we address i) What are the number and magnitude of changes in miRNA-expression between normal plasma cells...
20.
Bolomsky A, Hose D, Schreder M, Seckinger A, Lipp S, Klein B, et al.
J Hematol Oncol
. 2015 Apr;
8:10.
PMID: 25887188
Background: Insulin like growth factor binding protein 7 (IGFBP7) is a secreted protein binding insulin like growth factor 1 (IGF-1), insulin, vascular endothelial growth factor A (VEGFA), and activin A....