Bernard C H Lee
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Explore the profile of Bernard C H Lee including associated specialties, affiliations and a list of published articles.
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6
Citations
598
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Recent Articles
1.
Robinson P, Thomas L, Abascal F, Jung H, Harvey L, West H, et al.
Nat Commun
. 2022 Jul;
13(1):3949.
PMID: 35803914
Cellular DNA damage caused by reactive oxygen species is repaired by the base excision repair (BER) pathway which includes the DNA glycosylase MUTYH. Inherited biallelic MUTYH mutations cause predisposition to...
2.
Lee B, Robinson P, Coorens T, Yan H, Olafsson S, Lee-Six H, et al.
Nat Commun
. 2022 May;
13(1):2710.
PMID: 35581206
Lynch Syndrome (LS) is an autosomal dominant disease conferring a high risk of colorectal cancer due to germline heterozygous mutations in a DNA mismatch repair (MMR) gene. Although cancers in...
3.
Robinson P, Coorens T, Palles C, Mitchell E, Abascal F, Olafsson S, et al.
Nat Genet
. 2021 Oct;
53(10):1434-1442.
PMID: 34594041
Mutation accumulation in somatic cells contributes to cancer development and is proposed as a cause of aging. DNA polymerases Pol ε and Pol δ replicate DNA during cell division. However,...
4.
Yan H, Siu H, Ho S, Yue S, Gao Y, Tsui W, et al.
Gut
. 2020 Mar;
69(12):2165-2179.
PMID: 32217638
Objective: Sporadic early-onset colorectal cancer (EOCRC) has bad prognosis, yet is poorly represented by cell line models. We examine the key mutational and transcriptomic alterations in an organoid biobank enriched...
5.
Yan H, Siu H, Law S, Ho S, Yue S, Tsui W, et al.
Cell Stem Cell
. 2018 Oct;
23(6):882-897.e11.
PMID: 30344100
Gastric cancer displays marked molecular heterogeneity with aggressive behavior and treatment resistance. Therefore, good in vitro models that encompass unique subtypes are urgently needed for precision medicine development. Here, we...
6.
Yan H, Lai J, Ho S, Leung W, Lun Law W, Lee J, et al.
Gut
. 2016 Jun;
66(9):1645-1656.
PMID: 27329244
Objective: Serrated polyps (hyperplastic polyps, sessile or traditional serrated adenomas), which can arise in a sporadic or polyposis setting, predispose to colorectal cancer (CRC), especially those with microsatellite instability (MSI)...