Benjamin S Goldberg
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Explore the profile of Benjamin S Goldberg including associated specialties, affiliations and a list of published articles.
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8
Citations
73
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Recent Articles
1.
Goldberg B, Ackerman M
mBio
. 2024 Dec;
16(1):e0190024.
PMID: 39660921
The biologic activities of antibody drugs are dictated by structure-function relationships-emerging from the kind, composition, and degree of interactions with a target antigen and with soluble and cellular antibody receptors...
2.
Kelkar N, Goldberg B, Dufloo J, Bruel T, Schwartz O, Hessell A, et al.
mBio
. 2024 Feb;
15(3):e0028224.
PMID: 38385704
The complement system can be viewed as a "moderator" of innate immunity, "instructor" of humoral immunity, and "regulator" of adaptive immunity. While sex is known to affect humoral and cellular...
3.
Sex and species associated differences in Complement-mediated immunity in Humans and Rhesus macaques
Kelkar N, Goldberg B, Dufloo J, Bruel T, Schwartz O, Hessell A, et al.
bioRxiv
. 2023 Nov;
PMID: 37961263
The complement system can be viewed as a 'moderator' of innate immunity, 'instructor' of humoral immunity, and 'regulator' of adaptive immunity. While sex and aging are known to affect humoral...
4.
Goldberg B, Spencer D, Pandey S, Ordonez T, Barnette P, Yu Y, et al.
Proc Natl Acad Sci U S A
. 2023 May;
120(20):e2221247120.
PMID: 37155897
The first clinical efficacy trials of a broadly neutralizing antibody (bNAb) resulted in less benefit than expected and suggested that improvements are needed to prevent HIV infection. While considerable effort...
5.
Evidence for the Role of a Second Fc-Binding Receptor in Placental IgG Transfer in Nonhuman Primates
Rosenberg Y, Ordonez T, Khanwalkar U, Barnette P, Pandey S, Backes I, et al.
mBio
. 2023 Mar;
14(2):e0034123.
PMID: 36946726
Transplacental transfer of maternal antibodies provides the fetus and newborn with passive protection against infectious diseases. While the role of the highly conserved neonatal Fc receptor (FcRn) in transfer of...
6.
Spencer D, Goldberg B, Pandey S, Ordonez T, Dufloo J, Barnette P, et al.
Nat Commun
. 2022 Feb;
13(1):662.
PMID: 35115533
Increasingly, antibodies are being used to treat and prevent viral infections. In the context of HIV, efficacy is primarily attributed to dose-dependent neutralization potency and to a lesser extent Fc-mediated...
7.
Goldberg B, Kaku C, Dufloo J, Bruel T, Schwartz O, Spencer D, et al.
mBio
. 2021 Oct;
12(5):e0174321.
PMID: 34634936
The role of the complement system in HIV-1 immunity and pathogenesis is multifaceted, and an improved understanding of complement activities mediated by HIV-1-specific antibodies has the potential to inform and...
8.
Goldberg B, Ackerman M
Immunol Cell Biol
. 2020 Mar;
98(4):305-317.
PMID: 32142167
Antibody-dependent complement activity is associated not only with autoimmune morbidity, but also with antitumor efficacy. In infectious disease, both recombinant monoclonal antibodies and polyclonal antibodies generated in natural adaptive responses...