Benjamin Reidich
Overview
Explore the profile of Benjamin Reidich including associated specialties, affiliations and a list of published articles.
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6
Citations
70
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Recent Articles
1.
Garnsey M, Wang Y, Edmonds D, Sammons M, Reidich B, Ahn Y, et al.
Nat Commun
. 2025 Jan;
16(1):297.
PMID: 39746932
Several hydroxysteroid dehydrogenase 17-beta 13 variants have previously been identified as protective against metabolic dysfunction-associated steatohepatitis (MASH) fibrosis, ballooning and inflammation, and as such this target holds significant therapeutic potential....
2.
Londregan A, Wei L, Xiao J, Lintner N, Petersen D, Dullea R, et al.
J Med Chem
. 2018 Jun;
61(13):5704-5718.
PMID: 29878763
The optimization of a new class of small molecule PCSK9 mRNA translation inhibitors is described. The potency, physicochemical properties, and off-target pharmacology associated with the hit compound (1) were improved...
3.
McClure K, Piotrowski D, Petersen D, Wei L, Xiao J, Londregan A, et al.
Angew Chem Int Ed Engl
. 2017 Oct;
56(51):16218-16222.
PMID: 29073340
Targeting of the human ribosome is an unprecedented therapeutic modality with a genome-wide selectivity challenge. A liver-targeted drug candidate is described that inhibits ribosomal synthesis of PCSK9, a lipid regulator...
4.
Sanhueza C, Baksh M, Thuma B, Roy M, Dutta S, Preville C, et al.
J Am Chem Soc
. 2017 Feb;
139(9):3528-3536.
PMID: 28230359
A compact and stable bicyclic bridged ketal was developed as a ligand for the asialoglycoprotein receptor (ASGPR). This compound showed excellent ligand efficiency, and the molecular details of binding were...
5.
Skepner J, Shelly L, Ji C, Reidich B, Luo Y
Prostaglandins Other Lipid Mediat
. 2010 Nov;
94(1-2):3-8.
PMID: 21040800
Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites produced by cytochrome P450 epoxygenases which are highly expressed in hepatocytes. The functions of EETs in hepatocytes are not well understood. In this...
6.
Luo Y, Shelly L, Sand T, Reidich B, Chang G, Macdougall M, et al.
J Pharmacol Exp Ther
. 2009 Nov;
332(3):1100-6.
PMID: 19933370
Phospholipid transfer protein (PLTP) plays an important role in atherogenesis, and its function goes well beyond that of transferring phospholipids between lipoprotein particles. Previous studies showed that genetic deficiency of...