Benjamin P Fairfax
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Explore the profile of Benjamin P Fairfax including associated specialties, affiliations and a list of published articles.
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4480
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Recent Articles
1.
Watson R, Ye W, Taylor C, Jungkurth E, Cooper R, Tong O, et al.
J Immunother Cancer
. 2024 Apr;
12(4).
PMID: 38663935
We describe three cases of critical acute myositis with myocarditis occurring within 22 days of each other at a single institution, all within 1 month of receiving the initial cycle...
2.
Gilchrist J, Fang H, Danielli S, Tomkova M, Nassiri I, Ng E, et al.
Cell Genom
. 2024 Apr;
4(5):100541.
PMID: 38663408
To better understand inter-individual variation in sensitivity of DNA methylation (DNAm) to immune activity, we characterized effects of inflammatory stimuli on primary monocyte DNAm (n = 190). We find that...
3.
Chong A, Brenner N, Jimenez-Kaufmann A, Cortes A, Hill M, Littlejohns T, et al.
Am J Hum Genet
. 2024 Jan;
111(2):295-308.
PMID: 38232728
Infectious agents contribute significantly to the global burden of diseases through both acute infection and their chronic sequelae. We leveraged the UK Biobank to identify genetic loci that influence humoral...
4.
Mazet J, Mahale J, Tong O, Watson R, Lechuga-Vieco A, Pirgova G, et al.
Nat Commun
. 2023 Jan;
14(1):321.
PMID: 36658158
IFNγ is an immune mediator with concomitant pro- and anti-tumor functions. Here, we provide evidence that IFNγ directly acts on intra-tumoral CD8 T cells to restrict anti-tumor responses. We report...
5.
Taylor C, Watson R, Tong O, Ye W, Nassiri I, Gilchrist J, et al.
Nat Med
. 2022 Dec;
28(12):2592-2600.
PMID: 36526722
Treatment with immune checkpoint blockade (ICB) frequently triggers immune-related adverse events (irAEs), causing considerable morbidity. In 214 patients receiving ICB for melanoma, we observed increased severe irAE risk in minor...
6.
Gilchrist J, Auckland K, Parks T, Mentzer A, Goldblatt L, Naranbhai V, et al.
PLoS Pathog
. 2022 Sep;
18(9):e1010312.
PMID: 36121873
Leprosy is a chronic infection of the skin and peripheral nerves caused by Mycobacterium leprae. Despite recent improvements in disease control, leprosy remains an important cause of infectious disability globally....
7.
Gilchrist J, Makino S, Naranbhai V, Sharma P, Koturan S, Tong O, et al.
Nat Commun
. 2022 Jul;
13(1):4073.
PMID: 35835762
Natural Killer cells are innate lymphocytes with central roles in immunosurveillance and are implicated in autoimmune pathogenesis. The degree to which regulatory variants affect Natural Killer cell gene expression is...
8.
Ruffieux H, Davison A, Hager J, Inshaw J, Fairfax B, Richardson S, et al.
Ann Appl Stat
. 2022 Jan;
14(2):905-928.
PMID: 34992707
We tackle modelling and inference for variable selection in regression problems with many predictors and many responses. We focus on detecting , that is, predictors associated with several responses. Such...
9.
Peng Y, Felce S, Dong D, Penkava F, Mentzer A, Yao X, et al.
Nat Immunol
. 2021 Dec;
23(1):50-61.
PMID: 34853448
NP-B*07:02-specific CD8 T cell responses are considered among the most dominant in SARS-CoV-2-infected individuals. We found strong association of this response with mild disease. Analysis of NP-B*07:02-specific T cell clones...
10.
Watson R, Tong O, Cooper R, Taylor C, Sharma P, Verge de Los Aires A, et al.
Sci Immunol
. 2021 Oct;
6(64):eabj8825.
PMID: 34597125
The antitumor action of immune checkpoint blockade (ICB) is primarily mediated by CD8 T cells. How sensitivity to ICB varies across CD8 T cell subsets and clonotypes and the relationship...