Benjamin L Walker
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Explore the profile of Benjamin L Walker including associated specialties, affiliations and a list of published articles.
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9
Citations
102
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Recent Articles
1.
Coletti A, Newhall K, Walker B, Bloom K
ArXiv
. 2024 Jul;
PMID: 38979491
Within the nucleus, structural maintenance of chromosome protein complexes, namely condensin and cohesin, create an architecture to facilitate the organization and proper function of the genome. Condensin, in addition to...
2.
Interruption of the intratumor CD8 T cell:Treg crosstalk improves the efficacy of PD-1 immunotherapy
Geels S, Moshensky A, Sousa R, Murat C, Bustos M, Walker B, et al.
Cancer Cell
. 2024 Jun;
42(6):1051-1066.e7.
PMID: 38861924
PD-1 blockade unleashes potent antitumor activity in CD8 T cells but can also promote immunosuppressive T regulatory (Treg) cells, which may worsen the response to immunotherapy. Tumor-Treg inhibition is a...
3.
Kolbin D, Walker B, Hult C, Stanton J, Adalsteinsson D, Gregory Forest M, et al.
Genes (Basel)
. 2023 Dec;
14(12).
PMID: 38137015
Transient DNA loops occur throughout the genome due to thermal fluctuations of DNA and the function of SMC complex proteins such as condensin and cohesin. Transient crosslinking within and between...
4.
Walker B, Nie Q
Nat Commun
. 2023 Oct;
14(1):6554.
PMID: 37848426
Spatial gene expression in tissue is characterized by regions in which particular genes are enriched or depleted. Frequently, these regions contain nested inside them subregions with distinct expression patterns. Segmentation...
5.
Geels S, Moshensky A, Sousa R, Walker B, Singh R, Gutierrez G, et al.
bioRxiv
. 2023 Jun;
PMID: 37292782
PD-1 blockade unleashes the potent antitumor activity of CD8 cells but can also promote immunosuppressive T regulatory (Treg) cells, which may worsen response to immunotherapy. Tumor Treg inhibition is a...
6.
Walker B, Newhall K
Phys Rev E
. 2022 Jul;
105(6-1):064113.
PMID: 35854621
Stochastically switching force terms appear frequently in models of biological systems under the action of active agents such as proteins. The interaction of switching forces and Brownian motion can create...
7.
Ren H, Walker B, Cang Z, Nie Q
Nat Commun
. 2022 Jul;
13(1):4076.
PMID: 35835774
One major challenge in analyzing spatial transcriptomic datasets is to simultaneously incorporate the cell transcriptome similarity and their spatial locations. Here, we introduce SpaceFlow, which generates spatially-consistent low-dimensional embeddings by...
8.
Walker B, Cang Z, Ren H, Bourgain-Chang E, Nie Q
Commun Biol
. 2022 Mar;
5(1):220.
PMID: 35273328
The rapid development of spatial transcriptomics (ST) techniques has allowed the measurement of transcriptional levels across many genes together with the spatial positions of cells. This has led to an...
9.
Walker B, Newhall K
PLoS One
. 2018 Nov;
13(11):e0206977.
PMID: 30403739
Understanding information processing in the brain requires the ability to determine the functional connectivity between the different regions of the brain. We present a method using transfer entropy to extract...