Benjamin J Leslie
Overview
Explore the profile of Benjamin J Leslie including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
524
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0
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Recent Articles
1.
Leslie B, Lang B, Babu M
Nat Biotechnol
. 2023 Oct;
42(1):32-34.
PMID: 37783848
No abstract available.
2.
Singh N, Reyes-Ordonez A, Compagnone M, Moreno J, Leslie B, Ha T, et al.
Nat Commun
. 2021 Jul;
12(1):4339.
PMID: 34267198
Pleckstrin homology (PH) domains are presumed to bind phosphoinositides (PIPs), but specific interaction with and regulation by PIPs for most PH domain-containing proteins are unclear. Here we employ a single-molecule...
3.
Chowdhury F, Doganay S, Leslie B, Singh R, Amar K, Talluri B, et al.
Biochem Biophys Res Commun
. 2018 Apr;
500(3):557-563.
PMID: 29673588
Recently, a robust mechanical method has been established to isolate a small subpopulation of highly tumorigenic tumor repopulating cells (TRCs) from parental melanoma cells. In order to characterize the molecular...
4.
Masuda I, Igarashi T, Sakaguchi R, Nitharwal R, Takase R, Han K, et al.
Nucleic Acids Res
. 2016 Dec;
45(7):4081-4093.
PMID: 27956502
Transfer RNAs (tRNAs) perform essential tasks for all living cells. They are major components of the ribosomal machinery for protein synthesis and they also serve in non-ribosomal pathways for regulation...
5.
Chowdhury F, Li I, Ngo T, Leslie B, Kim B, Sokoloski J, et al.
Nano Lett
. 2016 May;
16(6):3892-7.
PMID: 27167603
Notch signaling, involved in development and tissue homeostasis, is activated at the cell-cell interface through ligand-receptor interactions. Previous studies have implicated mechanical forces in the activation of Notch receptor upon...
6.
Zhang J, Fei J, Leslie B, Han K, Kuhlman T, Ha T
Sci Rep
. 2015 Nov;
5:17295.
PMID: 26612428
Live cell RNA imaging using genetically encoded fluorescent labels is an important tool for monitoring RNA activities. A recently reported RNA aptamer-fluorogen system, the Spinach, in which an RNA aptamer...
7.
Chowdhury F, Li I, Leslie B, Doganay S, Singh R, Wang X, et al.
Integr Biol (Camb)
. 2015 Jul;
7(10):1265-1271.
PMID: 26143887
Cells' ability to sense and interpret mechanical signals from the extracellular milieu modulates the degree of cell spreading. Yet how cells detect such signals and activate downstream signaling at the...
8.
Liang Q, Seo G, Choi Y, Kwak M, Ge J, Rodgers M, et al.
Cell Host Microbe
. 2014 Feb;
15(2):228-38.
PMID: 24528868
Robust immune responses are essential for eliminating pathogens but must be metered to avoid prolonged immune activation and potential host damage. Upon recognition of microbial DNA, the cytosolic DNA sensor...
9.
Han K, Leslie B, Fei J, Zhang J, Ha T
J Am Chem Soc
. 2013 Nov;
135(50):19033-8.
PMID: 24286188
The use of aptamer-fluorogen complexes is an emerging strategy for RNA imaging. Despite its promise for cellular imaging and sensing, the low fluorescence intensity of the Spinach-DFHBI RNA aptamer-fluorogen complex...
10.
Lee G, Yoo J, Leslie B, Ha T
Nat Chem Biol
. 2011 May;
7(6):367-74.
PMID: 21552271
λ exonuclease degrades one strand of duplex DNA in the 5'-to-3' direction to generate a 3' overhang required for recombination. Its ability to hydrolyze thousands of nucleotides processively is attributed...