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Benjamin G Lilienfeld

Explore the profile of Benjamin G Lilienfeld including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 161
Followers 0
Related Specialties
General Surgery
Allergy & Immunology
Top 10 Co-Authors
Jorg D Seebach
Bettina C Baumann
Marten K J Schneider
Pietro Forte
Mark D Crew
Eckhard Wolf
Peter D Tran
Nicolas J Mueller
Rudiger Wanke
Lukas L Imbach
Published In
Xenotransplantation
Transplantation
J Immunol
Affiliations
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Recent Articles
1.
HLA-E/human beta2-microglobulin transgenic pigs: protection against xenogeneic human anti-pig natural killer cell cytotoxicity
Weiss E, Lilienfeld B, Muller S, Muller E, Herbach N, Kessler B, et al.
Transplantation . 2009 Jan; 87(1):35-43. PMID: 19136889
Background: Natural killer (NK) cells participate in pig-to-primate xenograft rejection both by antibody-dependent and -independent mechanisms. A majority of human NK cells express the inhibitory receptor CD94/NKG2A, which binds specifically...
2.
Porcine cells express more than one functional ligand for the human lymphocyte activating receptor NKG2D
Tran P, Christiansen D, Winterhalter A, Brooks A, Gorrell M, Lilienfeld B, et al.
Xenotransplantation . 2009 Jan; 15(5):321-32. PMID: 19134162
Background: Xenotransplantation could ameliorate the severe shortage of donor organs. The initial results of transplantation from genetically-modified pig donors to primate recipients suggest that hyperacute rejection can be overcome, but...
3.
Characterization of porcine UL16-binding protein 1 endothelial cell surface expression
Lilienfeld B, Schildknecht A, Imbach L, Mueller N, Schneider M, Seebach J
Xenotransplantation . 2008 May; 15(2):136-44. PMID: 18447887
Background: Natural killer (NK) cells participate in the immune response against solid organ allo- and xenografts and are tightly regulated through signals mediated by inhibiting and activating receptors expressed on...
4.
Transgenic expression of HLA-E single chain trimer protects porcine endothelial cells against human natural killer cell-mediated cytotoxicity
Lilienfeld B, Crew M, Forte P, Baumann B, Seebach J
Xenotransplantation . 2007 Mar; 14(2):126-34. PMID: 17381687
Background: The susceptibility of porcine endothelial cells (pEC) to human natural killer (NK) cells is related to the failure of human major histocompatibility complex (MHC)-specific killer inhibitory receptors to recognize...
5.
Porcine UL16-binding protein 1 expressed on the surface of endothelial cells triggers human NK cytotoxicity through NKG2D
Lilienfeld B, Garcia-Borges C, Crew M, Seebach J
J Immunol . 2006 Aug; 177(4):2146-52. PMID: 16887974
Cellular rejection mechanisms, including NK cells, remain a hurdle for successful pig-to-human xenotransplantation. Human anti-pig NK cytotoxicity depends on the activating receptor NKG2D. Porcine UL16-binding protein 1 (pULBP1) and porcine...
6.
Human NK cytotoxicity against porcine cells is triggered by NKp44 and NKG2D
Forte P, Lilienfeld B, Baumann B, Seebach J
J Immunol . 2005 Oct; 175(8):5463-70. PMID: 16210654
Pig-to-human xenotransplantation has been proposed as a means to alleviate the shortage of human organs for transplantation, but cellular rejection remains a hurdle for successful xenograft survival. NK cells have...
7.
Endothelial cells derived from pigs lacking Gal alpha(1,3)Gal: no reduction of human leukocyte adhesion and natural killer cell cytotoxicity
Baumann B, Schneider M, Lilienfeld B, Antsiferova M, Rhyner D, Hawley R, et al.
Transplantation . 2005 May; 79(9):1067-72. PMID: 15880045
Background: The expression of galactose-alpha(1,3)galactose (Gal) on porcine cells represents a major barrier to xenotransplantation. The generation of Gal-/- pigs to overcome this barrier redirected the focus of research to...