Benjamin E Mead
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Explore the profile of Benjamin E Mead including associated specialties, affiliations and a list of published articles.
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22
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2044
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Recent Articles
1.
Liu N, Kattan W, Mead B, Kummerlowe C, Cheng T, Ingabire S, et al.
Nat Biotechnol
. 2024 Oct;
PMID: 39375446
High-throughput phenotypic screens using biochemical perturbations and high-content readouts are constrained by limitations of scale. To address this, we establish a method of pooling exogenous perturbations followed by computational deconvolution...
2.
Seidelin J, Bronze M, Poulsen A, Attauabi M, Woetmann A, Mead B, et al.
Am J Physiol Gastrointest Liver Physiol
. 2024 May;
327(1):G70-G79.
PMID: 38713614
Although impaired regeneration is important in many gastrointestinal diseases including ulcerative colitis (UC), the dynamics of mucosal regeneration in humans are poorly investigated. We have developed a model to study...
3.
Tzouanas C, Sherman M, Shay J, Rubin A, Mead B, Dao T, et al.
bioRxiv
. 2023 Dec;
PMID: 38077056
Under chronic stress, cells must balance competing demands between cellular survival and tissue function. In metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD/NASH), hepatocytes cooperate with structural and immune cells...
4.
Mead B, Kummerlowe C, Liu N, Kattan W, Cheng T, Cheah J, et al.
bioRxiv
. 2023 Feb;
PMID: 36747859
High-throughput phenotypic screens leveraging biochemical perturbations, high-content readouts, and complex multicellular models could advance therapeutic discovery yet remain constrained by limitations of scale. To address this, we establish a method...
5.
Nyquist S, Gao P, Haining T, Retchin M, Golan Y, Drake R, et al.
Proc Natl Acad Sci U S A
. 2022 Apr;
119(15):e2121720119.
PMID: 35377806
Human breast milk (hBM) is a dynamic fluid that contains millions of cells, but their identities and phenotypic properties are poorly understood. We generated and analyzed single-cell RNA-sequencing (scRNA-seq) data...
6.
Mead B, Hattori K, Levy L, Imada S, Goto N, Vukovic M, et al.
Nat Biomed Eng
. 2022 Mar;
6(4):476-494.
PMID: 35314801
The cellular composition of barrier epithelia is essential to organismal homoeostasis. In particular, within the small intestine, adult stem cells establish tissue cellularity, and may provide a means to control...
7.
Genshaft A, Ziegler C, Tzouanas C, Mead B, Jaeger A, Navia A, et al.
Nat Commun
. 2021 Sep;
12(1):5361.
PMID: 34480027
No abstract available.
8.
Genshaft A, Ziegler C, Tzouanas C, Mead B, Jaeger A, Navia A, et al.
Nat Commun
. 2021 Aug;
12(1):4995.
PMID: 34404785
A cell's phenotype and function are influenced by dynamic interactions with its microenvironment. To examine cellular spatiotemporal activity, we developed SPACECAT-Spatially PhotoActivatable Color Encoded Cell Address Tags-to annotate, track, and...
9.
Seidelin J, Bahl M, Rask Licht T, Mead B, Karp J, Johansen J, et al.
Cell Mol Gastroenterol Hepatol
. 2021 Jun;
12(4):1281-1296.
PMID: 34118489
Background And Aims: The trigger hypothesis opens the possibility of anti-flare initiation therapies by stating that ulcerative colitis (UC) flares originate from inadequate responses to acute mucosal injuries. However, experimental...
10.
Carlone D, Riba-Wolman R, Deary L, Tovaglieri A, Jiang L, Ambruzs D, et al.
Stem Cells
. 2021 Jan;
39(3):296-305.
PMID: 33438789
Skeletal progenitor/stem cells (SSCs) play a critical role in postnatal bone growth and maintenance. Telomerase (Tert) activity prevents cellular senescence and is required for maintenance of stem cells in self-renewing...