Benjamin Chain
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Explore the profile of Benjamin Chain including associated specialties, affiliations and a list of published articles.
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35
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1664
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Recent Articles
11.
de Greef P, Oakes T, Gerritsen B, Ismail M, Heather J, Hermsen R, et al.
Elife
. 2020 Mar;
9.
PMID: 32187010
The clone size distribution of the human naive T-cell receptor (TCR) repertoire is an important determinant of adaptive immunity. We estimated the abundance of TCR sequences in samples of naive...
12.
Ciszek-Lenda M, Strus M, Walczewska M, Majka G, Machul-Zwirbla A, Mikolajczyk D, et al.
Inflamm Res
. 2019 Mar;
68(5):397-413.
PMID: 30887082
Objective: Pseudomonas aeruginosa effectively facilitate resistance to phagocyte killing by biofilm formation. However, the cross talk between biofilm components and phagocytes is still unclear. We hypothesize that a biofilm provides...
13.
Chain G, Marshall E, Geddie C, Joseph S, Chain B, Clark C
Scott Med J
. 2018 Sep;
63(4):104-107.
PMID: 30222067
Background And Aims: Learning from error can have a negative impact on the staff involved in the error ('second victim phenomenon'). We created a project, based on the principles of...
14.
Polonsky M, Rimer J, Kern-Perets A, Zaretsky I, Miller S, Bornstein C, et al.
Science
. 2018 Jun;
360(6394).
PMID: 29903938
Cell differentiation is directed by signals driving progenitors into specialized cell types. This process can involve collective decision-making, when differentiating cells determine their lineage choice by interacting with each other....
15.
Frampton D, Schwenzer H, Marino G, Butcher L, Pollara G, Kriston-Vizi J, et al.
Cancer Cell
. 2018 Apr;
33(4):620-633.e6.
PMID: 29634949
The canine transmissible venereal tumor (CTVT) is a clonally transmissible cancer that regresses spontaneously or after treatment with vincristine, but we know little about the regression mechanisms. We performed global...
16.
Roe J, Thomas N, Gil E, Best K, Tsaliki E, Morris-Jones S, et al.
JCI Insight
. 2016 Oct;
1(16):e87238.
PMID: 27734027
Novel rapid diagnostics for active tuberculosis (TB) are required to overcome the time delays and inadequate sensitivity of current microbiological tests that are critically dependent on sampling the site of...
17.
Kundu R, Theodoraki A, Haas C, Zhang Y, Chain B, Kriston-Vizi J, et al.
Immunology
. 2016 Sep;
150(1):55-63.
PMID: 27608289
Vitamin D is widely reported to inhibit innate immune signalling and dendritic cell (DC) maturation as a potential immunoregulatory mechanism. It is not known whether vitamin D has global or...
18.
Heather J, Best K, Oakes T, Gray E, Roe J, Thomas N, et al.
Front Immunol
. 2016 Jan;
6:644.
PMID: 26793190
HIV infection profoundly affects many parameters of the immune system and ultimately leads to AIDS, yet which factors are most important for determining resistance, pathology, and response to antiretroviral treatment...
19.
Polonsky M, Chain B, Friedman N
Immunol Cell Biol
. 2015 Nov;
94(3):242-9.
PMID: 26606974
Clonal expansion of lymphocytes is a hallmark of vertebrate adaptive immunity. A small number of precursor cells that recognize a specific antigen proliferate into expanded clones, differentiate and acquire various...
20.
Heather J, Chain B
Genomics
. 2015 Nov;
107(1):1-8.
PMID: 26554401
Determining the order of nucleic acid residues in biological samples is an integral component of a wide variety of research applications. Over the last fifty years large numbers of researchers...