Benedict J Chambers
Overview
Explore the profile of Benedict J Chambers including associated specialties, affiliations and a list of published articles.
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Articles
47
Citations
900
Followers
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Recent Articles
1.
Exploiting Mass Spectrometry to Unlock the Mechanism of Nanoparticle-Induced Inflammasome Activation
Gupta G, Kaur J, Bhattacharya K, Chambers B, Gazzi A, Furesi G, et al.
ACS Nano
. 2023 Aug;
17(17):17451-17467.
PMID: 37643371
Nanoparticles (NPs) elicit sterile inflammation, but the underlying signaling pathways are poorly understood. Here, we report that human monocytes are particularly vulnerable to amorphous silica NPs, as evidenced by single-cell-based...
2.
Palma Medina L, Babacic H, Dzidic M, Parke A, Garcia M, Maleki K, et al.
Respir Res
. 2023 Feb;
24(1):62.
PMID: 36829233
Background: COVID-19 remains a major public health challenge, requiring the development of tools to improve diagnosis and inform therapeutic decisions. As dysregulated inflammation and coagulation responses have been implicated in...
3.
Fernandes S, Srivastava N, Pedicone C, Sudan R, Luke E, Dungan O, et al.
iScience
. 2023 Feb;
26(2):106071.
PMID: 36818285
Here we extend the understanding of how chemical inhibition of SHIP paralogs controls obesity. We compare different classes of SHIP inhibitors and find that selective inhibitors of SHIP1 or SHIP2...
4.
Liu R, Muliadi V, Mou W, Li H, Yuan J, Holmberg J, et al.
Nat Commun
. 2022 Nov;
13(1):6545.
PMID: 36319641
No abstract available.
5.
Wagner A, Kadri N, Tibbitt C, van de Ven K, Bagawath-Singh S, Oliinyk D, et al.
iScience
. 2022 Oct;
25(10):105137.
PMID: 36185379
Although PD-1 was shown to be a hallmark of T cells exhaustion, controversial studies have been reported on the role of PD-1 on NK cells. Here, we found by flow...
6.
Liu R, Muliadi V, Mou W, Li H, Yuan J, Holmberg J, et al.
Nat Commun
. 2022 Sep;
13(1):5093.
PMID: 36064840
The hypoxia-inducible factors (HIFs) regulate the main transcriptional pathway of response to hypoxia in T cells and are negatively regulated by von Hippel-Lindau factor (VHL). But the role of HIFs...
7.
Luu T, Sondergaard J, Pena-Perez L, Kharazi S, Krstic A, Meinke S, et al.
Front Immunol
. 2022 Jun;
13:854312.
PMID: 35757763
Natural killer (NK) cells play roles in viral clearance and early surveillance against malignant transformation, yet our knowledge of the underlying mechanisms controlling their development and functions remain incomplete. To...
8.
Ljunggren H, Ask E, Cornillet M, Strunz B, Chen P, Muvva J, et al.
Scand J Immunol
. 2022 Jun;
:e13195.
PMID: 35652743
The Karolinska KI/K COVID-19 Immune Atlas project was conceptualized in March 2020 as a part of the academic research response to the developing SARS-CoV-2 pandemic. The aim was to rapidly...
9.
Silva C, Sundling C, Folkesson E, Froberg G, Nobrega C, Canto-Gomes J, et al.
Front Immunol
. 2021 Dec;
12:727300.
PMID: 34887849
Upon infection with (Mtb) the host immune response might clear the bacteria, control its growth leading to latent tuberculosis (LTB), or fail to control its growth resulting in active TB...
10.
Cornillet M, Strunz B, Rooyackers O, Ponzetta A, Chen P, Muvva J, et al.
Eur J Immunol
. 2021 Nov;
52(3):503-510.
PMID: 34837225
Corona disease 2019 (COVID-19) affects multiple organ systems. Recent studies have indicated perturbations in the circulating metabolome linked to COVID-19 severity. However, several questions pertain with respect to the metabolome...