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Begona O Alen

Explore the profile of Begona O Alen including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 38
Followers 0
Related Specialties
Molecular Biology
Biochemistry
Oncology
Top 10 Co-Authors
Angel Concha
Rosalia Gallego
Yolanda Pazos
Maria Otero Alen
Jesus P Camina
Felipe F Casanueva
Carlos S Mosteiro
Saioa Dominguez Hormaetxe
Tomas Garcia-Caballero
Maria Teresa Hermida-Romero
Published In
Int J Mol Sci
Mol Biol Cell
Cancers (Basel)
PLoS One
Cells
Affiliations
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Recent Articles
1.
Simultaneous Detection of Collagen I Alpha II and Cytokeratin 19 mRNA by Multiplex qPCR in Liquid Biopsy in Diagnosis of Patients with Resectable Solid Tumors
Estevez Perez L, Alen B, Otero Alen M, Hormaetxe S, Simon L, Concha A
Int J Mol Sci . 2024 Sep; 25(17). PMID: 39273514
The early detection of tumors is one of the key factors in increasing overall survival in cancer patients. A wide range of cancers still do not have a system of...
2.
Expression of Epithelial and Mesenchymal Markers in Plasmatic Extracellular Vesicles as a Diagnostic Tool for Neoplastic Processes
Alen B, Estevez-Perez L, Otero Alen M, Hormaetxe S, Simon L, Concha A
Int J Mol Sci . 2023 Feb; 24(4). PMID: 36834987
Tumor-derived extracellular vesicles (TD-EVs) have active roles as cancer hallmark enablers. EVs RNA of epithelial and stromal cells carry information that facilitates the communication processes that contribute to oncological progression,...
3.
Molecular Detection of Lymph Node Metastases in Lung Cancer Patients Using the One-Step Nucleic Acid Amplification Method:Clinical Significance and Prognostic Value
Hermida-Romero M, Estevez-Perez L, Alen B, Picchi F, Fernandez-Prado R, de la Torre-Bravos M, et al.
Cells . 2022 Dec; 11(24). PMID: 36552774
The one-step nucleic acid amplification (OSNA) method allows for the quantitative evaluation of the tumor burden in resected lymph nodes (LNs) in patients with lung cancer. This technique enables to...
4.
Molecular Targets in Lung Cancer: Study of the Evolution of Biomarkers Associated with Treatment with Tyrosine Kinase Inhibitors-Has NF1 Tumor Suppressor a Key Role in Acquired Resistance?
Alen B, Estevez-Perez L, Hermida-Romero M, Reguera-Arias A, Garcia-Campelo R, de la Torre-Bravos M, et al.
Cancers (Basel) . 2022 Jul; 14(14). PMID: 35884384
The application to clinical practice of liquid biopsy in patients with lung cancer has led to an advance in the diagnosis and monitoring of the disease. Detection of alterations in...
5.
The role of the obestatin/GPR39 system in human gastric adenocarcinomas
Alen B, Leal-Lopez S, Otero Alen M, Viano P, Garcia-Castro V, Mosteiro C, et al.
Oncotarget . 2015 Dec; 7(5):5957-71. PMID: 26716511
Obestatin, a 23-amino acid peptide encoded by the ghrelin gene, and the GPR39 receptor were reported to be involved in the control of mitogenesis of gastric cancer cell lines; however,...
6.
The NMR structure of human obestatin in membrane-like environments: insights into the structure-bioactivity relationship of obestatin
Alen B, Nieto L, Gurriaran-Rodriguez U, Mosteiro C, Alvarez-Perez J, Otero-Alen M, et al.
PLoS One . 2012 Oct; 7(10):e45434. PMID: 23056203
The quest for therapeutic applications of obestatin involves, as a first step, the determination of its 3D solution structure and the relationship between this structure and the biological activity of...
7.
The SHP-1 protein tyrosine phosphatase negatively modulates Akt signaling in the ghrelin/GHSR1a system
Lodeiro M, Alen B, Mosteiro C, Beiroa D, Nogueiras R, Theodoropoulou M, et al.
Mol Biol Cell . 2011 Sep; 22(21):4182-91. PMID: 21900501
The aim of the present study was to identify the signaling mechanism(s) responsible for the modulation of growth hormone secretagogue receptor type 1a (GHSR1a)-associated Akt activity. Ghrelin leads to the...