Begona Martin-Castillo
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Explore the profile of Begona Martin-Castillo including associated specialties, affiliations and a list of published articles.
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87
Citations
2895
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Recent Articles
1.
Mitochondrial priming and response to BH3 mimetics in "one-two punch" senogenic-senolytic strategies
Lopez J, Llop-Hernandez A, Verdura S, Serrano-Hervas E, Martinez-Balibrea E, Bosch-Barrera J, et al.
Cell Death Discov
. 2025 Mar;
11(1):91.
PMID: 40055336
A one-two punch sequential regimen of senescence-inducing agents followed by senolytic drugs has emerged as a novel therapeutic strategy in cancer. Unfortunately, cancer cells undergoing therapy-induced senescence (TIS) vary widely...
2.
Cuyas E, Pedarra S, Verdura S, Pardo M, Espin Garcia R, Serrano-Hervas E, et al.
Cell Death Discov
. 2024 Sep;
10(1):417.
PMID: 39349429
Fatty acid synthase (FASN)-catalyzed endogenous lipogenesis is a hallmark of cancer metabolism. However, whether FASN is an intrinsic mechanism of tumor cell defense against T cell immunity remains unexplored. To...
3.
Verdura S, Encinar J, Gratchev A, Llop-Hernandez A, Lopez J, Serrano-Hervas E, et al.
Phytomedicine
. 2024 Mar;
128:155493.
PMID: 38484626
Background: ID3 (inhibitor of DNA binding/differentiation-3) is a transcription factor that enables metastasis by promoting stem cell-like properties in endothelial and tumor cells. The milk thistle flavonolignan silibinin is a...
4.
Menendez J, Cuyas E, Encinar J, Steen T, Verdura S, Llop-Hernandez A, et al.
Mol Oncol
. 2023 Dec;
18(3):479-516.
PMID: 38158755
The initial excitement generated more than two decades ago by the discovery of drugs targeting fatty acid synthase (FASN)-catalyzed de novo lipogenesis for cancer therapy was short-lived. However, the advent...
5.
Cuyas E, Verdura S, Martin-Castillo B, Menendez J
Aging (Albany NY)
. 2022 Dec;
15(4):892-897.
PMID: 36490309
The mitokine MOTS-c is a mitochondrially-encoded "exercise-mimetic peptide" expressed in multiple tissues, particularly skeletal muscles, which can be detected as a circulating hormone in the blood. MOTS-c mechanisms of action...
6.
Cuyas E, Martin-Castillo B, Menendez J
Aging (Albany NY)
. 2022 Jul;
14(14):5612-5613.
PMID: 35852878
No abstract available.
7.
Cejuela M, Martin-Castillo B, Menendez J, Pernas S
Int J Mol Sci
. 2022 Mar;
23(5).
PMID: 35269852
Breast cancer is the most prevalent cancer and the leading cause of cancer-related death among women worldwide. Type 2 diabetes-associated metabolic traits such as hyperglycemia, hyperinsulinemia, inflammation, oxidative stress, and...
8.
Bosch-Barrera J, Roque A, Teixidor E, Carmona-Garcia M, Arbusa A, Brunet J, et al.
Pharmaceuticals (Basel)
. 2022 Jan;
15(1).
PMID: 35056076
COVID-19 pathophysiology is caused by a cascade of respiratory and multiorgan failures arising, at least in part, from the SARS-CoV-2-driven dysregulation of the master transcriptional factor STAT3. Pharmacological correction of...
9.
Tramonti A, Cuyas E, Encinar J, Pietzke M, Paone A, Verdura S, et al.
Cancers (Basel)
. 2021 Aug;
13(16).
PMID: 34439169
The anticancer actions of the biguanide metformin involve the functioning of the serine/glycine one-carbon metabolic network. We report that metformin directly and specifically targets the enzymatic activity of mitochondrial serine...
10.
Cuyas E, Verdura S, Martin-Castillo B, Menendez J
Front Oncol
. 2021 Feb;
10:620641.
PMID: 33604300
Metabolism can directly drive or indirectly enable an aberrant chromatin state of cancer cells. The physiological and molecular principles of the metabolic link to epigenetics provide a basis for pharmacological...