Beate E Kehrel
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Explore the profile of Beate E Kehrel including associated specialties, affiliations and a list of published articles.
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51
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1181
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Recent Articles
1.
Poti F, Scalera E, Feuerborn R, Fischer J, Arndt L, Varga G, et al.
JCI Insight
. 2024 Nov;
9(24).
PMID: 39531328
Sphingosine 1-phosphate (S1P) is a lysosphingolipid with antiatherogenic properties, but mechanisms underlying its effects remain unclear. We here investigated atherosclerosis development in cholesterol-rich diet-fed LDL receptor-deficient mice with high or...
2.
Jurk K, Kehrel B
Semin Thromb Hemost
. 2023 Dec;
50(5):794-803.
PMID: 38086407
This article represents a republication of an article originally published in STH in 2005. This republication is to help celebrate 50 years of publishing for STH. The original abstract follows.Platelets...
3.
Schonichen C, Montague S, Brouns S, Burston J, Cosemans J, Jurk K, et al.
Arterioscler Thromb Vasc Biol
. 2023 Jul;
43(9):1700-1712.
PMID: 37409530
Background: Platelets and neutrophils are the first blood cells accumulating at sites of arterial thrombus formation, and both cell types contribute to the pathology of thrombotic events. We aimed to...
4.
Leidecker M, Bertling A, Hussain M, Bischoff M, Eble J, Fender A, et al.
Microbiol Spectr
. 2023 Mar;
11(3):e0388622.
PMID: 36995240
Invasion of host cells is an important feature of Staphylococcus aureus. The main internalization pathway involves binding of the bacteria to host cells, e.g., endothelial cells, via a fibronectin (Fn)...
5.
Olaizola I, Brodde M, Kehrel B, Evers S
J Clin Med
. 2023 Feb;
12(3).
PMID: 36769581
It is known that valproate inhibits platelet functions; however, the exact mechanisms are not clearly identified. We studied 12 healthy adult volunteers (1 female, 11 male; age range 31.7 ±...
6.
Vogelsang A, Eichler S, Huntemann N, Masanneck L, Bohnlein H, Schungel L, et al.
Int J Mol Sci
. 2021 Sep;
22(18).
PMID: 34576080
Aside from the established immune-mediated etiology of multiple sclerosis (MS), compelling evidence implicates platelets as important players in disease pathogenesis. Specifically, numerous studies have highlighted that activated platelets promote the...
7.
Herken K, Glauner M, Robert S, Maas M, Zippel S, Nowak-Gottl U, et al.
Int J Mol Sci
. 2021 Jun;
22(9).
PMID: 34063076
Platelet function is developmentally regulated. Healthy neonates do not spontaneously bleed, but their platelets are hypo-reactive to several agonists. The mechanisms underlying immature platelet function in neonates are incompletely understood....
8.
Pielsticker C, Brodde M, Raum L, Jurk K, Kehrel B
Int J Mol Sci
. 2020 Nov;
21(22).
PMID: 33238433
Inflammatory processes are triggered by the fibrinolytic enzyme plasmin. Tissue-type plasminogen activator, which cleaves plasminogen to plasmin, can be activated by the cross-β-structure of misfolded proteins. Misfolded protein aggregates also...
9.
Lehwald N, Duhme C, Pinchuk I, Kirchner J, Wieferich K, Schmelzle M, et al.
Int J Mol Sci
. 2020 Sep;
21(17).
PMID: 32899390
We previously demonstrated that clinical administration of mobilized CD133 bone marrow stem cells (BMSC) accelerates hepatic regeneration. Here, we investigated the potential of platelets to modulate CD133BMSC homing to hepatic...
10.
Dohrmann M, Makhoul S, Gross K, Krause M, Pillitteri D, von Auer C, et al.
FASEB J
. 2020 May;
34(7):9337-9357.
PMID: 32463151
Thrombin converts fibrinogen to fibrin and activates blood and vascular cells in thrombo-inflammatory diseases. Platelets are amplifiers of thrombin formation when activated by leukocyte- and vascular cell-derived thrombin. CD36 on...