Bastian Grewe
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Explore the profile of Bastian Grewe including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
236
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Recent Articles
1.
Grewe B, Vogt C, Horstkotter T, Tippler B, Xiao H, Muller B, et al.
Viruses
. 2021 Jun;
13(6).
PMID: 34071819
Alternative splicing and the expression of intron-containing mRNAs is one hallmark of HIV gene expression. To facilitate the otherwise hampered nuclear export of non-fully processed mRNAs, HIV encodes the Rev...
2.
Xiao H, Wyler E, Milek M, Grewe B, Kirchner P, Ekici A, et al.
mBio
. 2021 Jan;
12(1).
PMID: 33468685
The HIV-1 Rev protein is a nuclear export factor for unspliced and incompletely spliced HIV-1 RNAs. Without Rev, these intron-retaining RNAs are trapped in the nucleus. A genome-wide screen identified...
3.
Kolenbrander A, Grewe B, Nemazee D, Uberla K, Temchura V
Immunology
. 2017 Sep;
153(2):214-224.
PMID: 28881401
The minimum requirements for in vitro modelling of natural CD4 T-cell differentiation into T follicular helper (Tfh) cells are still under investigation. We co-cultured wild-type and T-cell receptor (TCR) transgenic...
4.
Ambrosius B, Faissner S, Guse K, von Lehe M, Grunwald T, Gold R, et al.
J Neuroinflammation
. 2017 Mar;
14(1):51.
PMID: 28284222
HIV-associated neurocognitive disorders (HAND) affect about 50% of infected patients despite combined antiretroviral therapy (cART). Ongoing compartmentalized inflammation mediated by microglia which are activated by HIV-infected monocytes has been postulated...
5.
Faissner S, Ambrosius B, Schanzmann K, Grewe B, Potthoff A, Munch J, et al.
Exp Neurol
. 2014 Aug;
261:685-97.
PMID: 25150097
Despite highly active antiretroviral therapy, HIV-associated neurocognitive disorders (HAND) are still highly prevalent. Direct neurotoxicity of microglia activated by HIV-infected monocytes independent from viral replication may account for this observation....
6.
Gardt O, Grewe B, Tippler B, Uberla K, Temchura V
Vaccine
. 2013 Sep;
31(44):5088-98.
PMID: 24029115
In animal models, lentiviral particles (LP) were shown to be promising HIV vaccine candidates. Since little is known about the direct impact of LP on antigen-specific B cells, we incorporated...
7.
Grewe B, Ehrhardt K, Hoffmann B, Blissenbach M, Brandt S, Uberla K
PLoS One
. 2012 Nov;
7(11):e48688.
PMID: 23133650
Background: During the RNA encapsidation process of human immunodeficiency virus (HIV) viral genomic, unspliced RNA (gRNA) is preferentially incorporated into assembling virions. However, a certain amount of spliced viral transcripts...
8.
Toukam D, Tenbusch M, Stang A, Temchura V, Storcksdieck Genannt Bonsmann M, Grewe B, et al.
PLoS One
. 2012 Jun;
7(5):e38068.
PMID: 22666448
Although human immunodeficiency type 1 (HIV-1) infection induces strong antibody responses to the viral envelope glycoprotein (Env) only a few of these antibodies possess the capacity to neutralize a broad...
9.
Grewe B, Hoffmann B, Ohs I, Blissenbach M, Brandt S, Tippler B, et al.
J Virol
. 2012 Jan;
86(6):2990-3002.
PMID: 22258250
In some retroviruses, such as Rous sarcoma virus and prototype foamy virus, Gag proteins are known to shuttle between the nucleus and the cytoplasm and are implicated in nuclear export...
10.
Grewe B, Uberla K
J Gen Virol
. 2010 Jun;
91(Pt 8):1893-1897.
PMID: 20538907
The Rev protein of human immunodeficiency viruses (HIV) has long been recognized to be essential for the late phase of the virus replication cycle, due to its strong enhancement of...