Bart M Gadella
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Explore the profile of Bart M Gadella including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Leemans B, Gadella B, Marchand J, Van Soom A, Stout T
Biol Reprod
. 2024 Jun;
111(3):580-599.
PMID: 38847468
We recently developed re-differentiated equine oviduct epithelial cell (REOEC) monolayers demonstrating various in vivo morphological characteristics, but lacking secondary ciliation. In this study, we evaluated the effects of fetal bovine...
2.
Zhang M, Chiozzi R, Bromfield E, Heck A, Helms J, Gadella B
Andrology
. 2023 Feb;
11(7):1460-1471.
PMID: 36815564
Background: Previously, we reported that cysteine-rich secretory protein 2 is involved in high molecular weight complexes in boar spermatozoa. These cysteine-rich secretory protein 2protein complexes are formed at the last...
3.
Aardema H, Vos P, Gadella B
Anim Reprod
. 2022 Oct;
15(Suppl 1):737-750.
PMID: 36249840
In the cow a major characteristic of metabolic stress is an elevated level of plasma free fatty acid, due to increased lipid mobilization from adipose tissue. Elevated levels of free...
4.
The fate of porcine sperm CRISP2 from the perinuclear theca before and after in vitro fertilization†
Zhang M, Bromfield E, Helms J, Gadella B
Biol Reprod
. 2022 Sep;
107(5):1242-1253.
PMID: 36054334
In a previous study, we reported that porcine sperm cysteine-rich secretory protein 2 (CRISP2) is localized in the post-acrosomal sheath-perinuclear theca (PT) as reduction-sensitive oligomers. In the current study, the...
5.
Pavani K, Meese T, Pascottini O, Guan X, Lin X, Peelman L, et al.
Proc Natl Acad Sci U S A
. 2022 Mar;
119(12):e2122708119.
PMID: 35298333
SignificanceHatching from the zona pellucida is a prerequisite for embryo implantation and is less likely to occur in vitro for reasons unknown. Extracellular vesicles (EVs) are secreted by the embryo...
6.
Zhang M, Chiozzi R, Skerrett-Byrne D, Veenendaal T, Klumperman J, Heck A, et al.
Front Cell Dev Biol
. 2022 Mar;
10:836208.
PMID: 35252197
The perinuclear theca (PT) is a highly condensed, largely insoluble protein structure that surrounds the nucleus of eutherian spermatozoa. Recent reports have indicated that the PT unexpectedly houses several somatic...
7.
Leemans B, Bromfield E, Stout T, Vos M, Van Der Ham H, Van Beek R, et al.
Biol Reprod
. 2021 Dec;
106(4):710-729.
PMID: 34962550
We describe the development of two methods for obtaining confluent monolayers of polarized, differentiated equine oviduct epithelial cells (EOEC) in Transwell inserts and microfluidic chips. EOECs from the ampulla were...
8.
Leung M, Ravi R, Gadella B, Zeev-Ben-Mordehai T
Front Cell Dev Biol
. 2021 Dec;
9:765673.
PMID: 34957098
To become fertilization-competent, mammalian sperm must undergo a complex series of biochemical and morphological changes in the female reproductive tract. These changes, collectively called capacitation, culminate in the exocytosis of...
9.
Maitan P, Bromfield E, Hoogendijk R, Leung M, Zeev-Ben-Mordehai T, van de Lest C, et al.
Front Cell Dev Biol
. 2021 Dec;
9:772254.
PMID: 34869370
Classical fertilization (IVF) is still poorly successful in horses. This lack of success is thought to be due primarily to inadequate capacitation of stallion spermatozoa under conditions. In species in...
10.
Leung M, Chiozzi R, Roelofs M, Hevler J, Ravi R, Maitan P, et al.
Proc Natl Acad Sci U S A
. 2021 Nov;
118(45).
PMID: 34737233
Mitochondria-cytoskeleton interactions modulate cellular physiology by regulating mitochondrial transport, positioning, and immobilization. However, there is very little structural information defining mitochondria-cytoskeleton interfaces in any cell type. Here, we use cryofocused...