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Barbara Ulmasov

Explore the profile of Barbara Ulmasov including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 15
Citations 298
Followers 0
Related Specialties
Gastroenterology
Cell Biology
Physiology
Top 10 Co-Authors
Brent A Neuschwander-Tetri
Kiyoko Oshima
David A Ford
Jonathan Bruno
John C Edwards
Hidenao Noritake
Gul N Shah
Sandip Mukherjee
Danielle Carpenter
Masahiro Umemura
Published In
Proc Natl Acad Sci U S A
Am J Pathol
Mol Metab
Am J Physiol Gastrointest Liver Physiol
Hepatol Commun
Affiliations
Soon will be listed here.
Recent Articles
1.
Inhibition of integrin binding to ligand arg-gly-asp motif induces AKT-mediated cellular senescence in hepatic stellate cells
Kitsugi K, Noritake H, Matsumoto M, Hanaoka T, Umemura M, Yamashita M, et al.
Mol Cell Biochem . 2023 Oct; 479(10):2697-2710. PMID: 37902885
Background & Aims: Hepatic stellate cells (HSCs) play an essential role in liver fibrogenesis. The induction of cellular senescence has been reported to inhibit HSC activation. Previously, we demonstrated that...
2.
Ube4A maintains metabolic homeostasis and facilitates insulin signaling in vivo
Mukherjee S, Chakraborty M, Msengi E, Haubner J, Zhang J, Jellinek M, et al.
Mol Metab . 2023 Jul; 75:101767. PMID: 37429524
Objective: Defining the regulators of cell metabolism and signaling is essential to design new therapeutic strategies in obesity and NAFLD/NASH. E3 ubiquitin ligases control diverse cellular functions by ubiquitination-mediated regulation...
3.
Enhancing Hepatic MBOAT7 Expression in Mice With Nonalcoholic Steatohepatitis
Sharpe M, Pyles K, Hallcox T, Kamm D, Piechowski M, Fisk B, et al.
Gastro Hep Adv . 2023 Jun; 2(4):558-572. PMID: 37293574
Background And Aims: Polymorphisms near the membrane bound O-acyltransferase domain containing 7 (MBOAT7) genes are associated with worsened nonalcoholic fatty liver (NASH), and nonalcoholic fatty liver disease (NAFLD)/NASH may decrease...
4.
Arg-Gly-Asp-binding integrins activate hepatic stellate cells via the hippo signaling pathway
Kitsugi K, Noritake H, Matsumoto M, Hanaoka T, Umemura M, Yamashita M, et al.
Cell Signal . 2022 Aug; 99:110437. PMID: 35970425
Background & Aims: Liver fibrosis characterizes advanced chronic liver disease, and persistent activation of hepatic stellate cells (HSCs) is the primary cause of excessive hepatic fibrogenesis. CWHM12, an analog of...
5.
Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis
Mukherjee S, Chakraborty M, Ulmasov B, McCommis K, Zhang J, Carpenter D, et al.
Mol Metab . 2021 Nov; 54:101364. PMID: 34757046
Objective: Obesity and insulin resistance greatly increase the risk of nonalcoholic fatty liver disease and steatohepatitis (NAFLD/NASH). We have previously discovered that whole-body and adipocyte-specific Ip6k1deletion protects mice from high-fat-diet-induced...
6.
An Inhibitor of Arginine-Glycine-Aspartate-Binding Integrins Reverses Fibrosis in a Mouse Model of Nonalcoholic Steatohepatitis
Ulmasov B, Noritake H, Carmichael P, Oshima K, Griggs D, Neuschwander-Tetri B
Hepatol Commun . 2019 Feb; 3(2):246-261. PMID: 30766962
The presence and stage of liver fibrosis in patients with nonalcoholic steatohepatitis (NASH) is strongly associated with mortality. Thus, both preventing and reversing fibrosis are critically important approaches to prevent...
7.
CLIC1 null mice demonstrate a role for CLIC1 in macrophage superoxide production and tissue injury
Ulmasov B, Bruno J, Oshima K, Cheng Y, Holly S, Parise L, et al.
Physiol Rep . 2017 Mar; 5(5). PMID: 28275112
We generated and studied CLIC1 null (C1KO) mice to investigate the physiological role of this protein. C1KO and matched wild-type (WT) mice were studied in two models of acute toxic...
8.
Inhibitors of Arg-Gly-Asp-Binding Integrins Reduce Development of Pancreatic Fibrosis in Mice
Ulmasov B, Neuschwander-Tetri B, Lai J, Monastyrskiy V, Bhat T, Yates M, et al.
Cell Mol Gastroenterol Hepatol . 2017 Feb; 2(4):499-518. PMID: 28174730
Background & Aims: Pancreatic stellate cells (PSCs) regulate the development of chronic pancreatitis (CP) and are activated by the cytokine transforming growth factor β (TGFB). Integrins of the αv family...
9.
Differences in the degree of cerulein-induced chronic pancreatitis in C57BL/6 mouse substrains lead to new insights in identification of potential risk factors in the development of chronic pancreatitis
Ulmasov B, Oshima K, Rodriguez M, Cox R, Neuschwander-Tetri B
Am J Pathol . 2013 Jul; 183(3):692-708. PMID: 23845568
A frequently used experimental model of chronic pancreatitis (CP) recapitulating human disease is repeated injection of cerulein into mice. C57BL/6 is the most commonly used inbred mouse strain for biomedical...
10.
Angiotensin II signaling through the AT1a and AT1b receptors does not have a role in the development of cerulein-induced chronic pancreatitis in the mouse
Ulmasov B, Xu Z, Talkad V, Oshima K, Neuschwander-Tetri B
Am J Physiol Gastrointest Liver Physiol . 2010 Apr; 299(1):G70-80. PMID: 20413721
The intraorgan renin-angiotensin system (RAS) plays an important role in the pathophysiology of a variety of diseases and has been implicated in fibrogenesis. The role of RAS in the development...