Barbara Huisamen
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Explore the profile of Barbara Huisamen including associated specialties, affiliations and a list of published articles.
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38
Citations
551
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Recent Articles
1.
Bester D, Blignaut M, Huisamen B
Biochem Biophys Res Commun
. 2024 Jul;
732:150422.
PMID: 39033549
The endoplasmic reticulum (ER) responds to cellular stress by initiating an unfolded protein response (UPR) that mitigates misfolded protein accumulation by promoting protein degradation pathways. Chronic ER stress leads to...
2.
Sangweni N, Gabuza K, van Aarde R, Mabasa L, van Vuuren D, Huisamen B, et al.
Int J Mol Sci
. 2023 Oct;
24(20).
PMID: 37895075
The therapeutic properties of flavonoids are reported to offer cardioprotective benefits against doxorubicin (Dox)-induced cardiotoxicity (DIC). In the current study, we aimed to investigate the prophylactic properties of 7-hydroxyflavanone (7H),...
3.
Sangweni N, van Vuuren D, Mabasa L, Gabuza K, Huisamen B, Naidoo S, et al.
Front Cardiovasc Med
. 2022 Jul;
9:907266.
PMID: 35811736
Doxorubicin (Dox)-induced cardiotoxicity (DIC) remains a serious health burden, especially in developing countries. Unfortunately, the high cost of current preventative strategies has marginalized numerous cancer patients because of socio-economic factors....
4.
Sangweni N, Gabuza K, Huisamen B, Mabasa L, van Vuuren D, Johnson R
Arch Toxicol
. 2022 Mar;
96(6):1541-1550.
PMID: 35333943
A breakthrough in oncology research was the discovery of doxorubicin (Dox) in the 1960's. Unlike other chemotherapy drugs, Dox was determined to have a greater therapeutic index. Since its discovery,...
5.
Blignaut M, Harries S, Lochner A, Huisamen B
Oxid Med Cell Longev
. 2021 Apr;
2021:8850708.
PMID: 33868575
Ataxia Telangiectasia Mutated protein kinase (ATM) has recently come to the fore as a regulatory protein fulfilling many roles in the fine balancing act of metabolic homeostasis. Best known for...
6.
Obasa Z, van Vuuren M, Huisamen B, Windvogel S
Cardiovasc J Afr
. 2021 Feb;
32(2):87-97.
PMID: 33605975
Purpose: Obesity is associated with the development of risk factors for cardiovascular disease (CVD) and polyphenols have been shown to possess ameliorative effects against obesity-induced CVD risk factors. Rooibos ()...
7.
Smit S, Manirafasha C, Marais E, Johnson R, Huisamen B
Planta Med
. 2020 Dec;
88(1):62-78.
PMID: 33285593
Diabetic patients develop ischemic heart disease and strokes more readily. Following an ischemic event, restoration of blood flow increases oxidative stress resulting in myocardial damage, termed ischemia/reperfusion injury. Aspalathus linearis...
8.
Sangweni N, Moremane M, Riedel S, van Vuuren D, Huisamen B, Mabasa L, et al.
Front Pharmacol
. 2020 Sep;
11:1172.
PMID: 32903793
Background: The clinical use of Doxorubicin (Dox) is significantly limited by its dose-dependent cardiotoxic side effect. Accumulative evidence suggests that the use of flavonoids, such as the antioxidative Pinocembrin (Pin),...
9.
Dhanabalan K, Mzezewa S, Huisamen B, Lochner A
Cardiovasc Drugs Ther
. 2020 May;
34(6):799-811.
PMID: 32458321
Purpose: Oxidative stress causes mitochondrial dysfunction in myocardial ischaemia/reperfusion (I/R) as well as in obesity. Mitochondrial depolarization triggers mitophagy to degrade damaged mitochondria, a process important for quality control. The...
10.
Dludla P, Muller C, Louw J, Mazibuko-Mbeje S, Tiano L, Silvestri S, et al.
Nutrients
. 2020 Apr;
12(4).
PMID: 32325968
Recent evidence shows that rooibos compounds, aspalathin and phenylpyruvic acid-2--β-D-glucoside (PPAG), can independently protect cardiomyocytes from hyperglycemia-related reactive oxygen species (ROS). While aspalathin shows more potency by enhancing intracellular antioxidant...