Barbara Brouwers
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Explore the profile of Barbara Brouwers including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Brouwers B, Fumagalli D, Brohee S, Hatse S, Govaere O, Floris G, et al.
Breast Cancer Res
. 2017 Jul;
19(1):78.
PMID: 28673354
Background: Tumours are not only composed of malignant cells but also consist of a stromal micro-environment, which has been shown to influence cancer cell behaviour. Because the ageing process induces...
12.
Shimelis H, Mesman R, von Nicolai C, Ehlen A, Guidugli L, Martin C, et al.
Cancer Res
. 2017 Mar;
77(11):2789-2799.
PMID: 28283652
Breast cancer risks conferred by many germline missense variants in the and genes, often referred to as variants of uncertain significance (VUS), have not been established. In this study, associations...
13.
Bailur J, Pawelec G, Hatse S, Brouwers B, Smeets A, Neven P, et al.
Breast Cancer Res
. 2017 Mar;
19(1):20.
PMID: 28241844
Background: Effective therapeutic management of elderly patients with cancer, on an individual basis, remains a clinical challenge. Here, we identify novel biomarkers to assess elderly patients (≥70 years of age)...
14.
Brouwers B, Hatse S, Dal Lago L, Neven P, Vuylsteke P, Dalmasso B, et al.
Oncotarget
. 2016 Apr;
7(21):29977-88.
PMID: 27102154
Purpose: This prospective observational study aimed to evaluate the impact of adjuvant chemotherapy on biological and clinical markers of aging and frailty. Methods: Women ≥ 70 years old with early...
15.
Brouwers B, Dalmasso B, Hatse S, Laenen A, Kenis C, Swerts E, et al.
Aging (Albany NY)
. 2015 May;
7(5):319-33.
PMID: 25989735
Older cancer patients are a highly heterogeneous population in terms of global health and physiological reserves, and it is often difficult to determine the best treatment. Moreover, clinical tools currently...
16.
Hatse S, Brouwers B, Dalmasso B, Laenen A, Kenis C, Schoffski P, et al.
PLoS One
. 2014 Oct;
9(10):e110644.
PMID: 25333486
Circulating microRNAs (miRNAs) hold great promise as easily accessible biomarkers for diverse (patho)physiological processes, including aging. We have compared miRNA expression profiles in cell-free blood from older versus young breast...
17.
Pallis A, Hatse S, Brouwers B, Pawelec G, Falandry C, Wedding U, et al.
J Geriatr Oncol
. 2014 Feb;
5(2):204-18.
PMID: 24495695
Aging of an individual entails a progressive decline of functional reserves and loss of homeostasis that eventually lead to mortality. This process is highly individualized and is influenced by multiple...
18.
Bojesen S, Pooley K, Johnatty S, Beesley J, Michailidou K, Tyrer J, et al.
Nat Genet
. 2013 Mar;
45(4):371-84, 384e1-2.
PMID: 23535731
TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ∼480 SNPs at the TERT locus in...
19.
Dreyer G, Vandorpe T, Smeets A, Forceville K, Brouwers B, Neven P, et al.
Breast
. 2013 Feb;
22(5):761-6.
PMID: 23416046
Purpose: To investigate the clinical behavior of triple negative breast cancer (TNC), including age distribution, occurrence of LN (lymph node) invasion and prognosis in different histological subtypes. Methods: For this...
20.
Hatse S, Lambrechts D, Verstuyf A, Smeets A, Brouwers B, Vandorpe T, et al.
Carcinogenesis
. 2012 May;
33(7):1319-26.
PMID: 22623648
We correlated serum 25-hydroxyvitamin D(3) (25OHD) levels with tumor characteristics and clinical disease outcome in breast cancer patients and assessed the impact of genetic determinants of vitamin D insufficiency. We...