B Popko
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Explore the profile of B Popko including associated specialties, affiliations and a list of published articles.
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50
Citations
1413
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Recent Articles
1.
Gao X, Gillig T, Ye P, DErcole A, Matsushima G, Popko B
Mol Cell Neurosci
. 2000 Nov;
16(4):338-49.
PMID: 11085872
Evidence suggests that interferon-gamma (IFN-gamma), a proinflammatory cytokine secreted by activated T lymphocytes, contributes a deleterious effect to immune-mediated demyelinating disorders such as multiple sclerosis and experimental autoimmune encephalomyelitis (EAE)....
2.
Marcus J, Dupree J, Popko B
Glia
. 2000 May;
30(4):319-28.
PMID: 10797612
The galactolipids galactocerebroside and sulfatide, which require the enzyme UDP-galactose:ceramide galactosyltransferase (CGT) for their synthesis, are among the most prevalent molecules in the myelin sheath. Numerous studies, mainly using antibody...
3.
Dupree J, Popko B
J Neurocytol
. 2000 Mar;
28(4-5):271-9.
PMID: 10739570
The roles that the myelin galactolipids galactocerebroside (GalC) and sulfatide play in cellular differentiation, myelin formation and maintenance have been investigated for nearly 3 decades. During that time the primary...
4.
Ezoe T, Vanier M, Oya Y, Popko B, Tohyama J, Matsuda J, et al.
J Neurosci Res
. 2000 Jan;
59(2):179-87.
PMID: 10650876
Cross-breeding of mouse mutants, each defective in either synthesis (CGT knockout) or degradation (twitcher) of galactosylceramide, generates hybrids with a genotype of galc -/-, cgt +/-, in addition to doubly...
5.
Ezoe T, Vanier M, Oya Y, Popko B, Tohyama J, Matsuda J, et al.
J Neurosci Res
. 2000 Jan;
59(2):170-8.
PMID: 10650875
We have generated mice doubly deficient in both synthesis and degradation of galactosylceramide by cross-breeding twitcher mice and galactosylceramide synthase (UDP-galactose:ceramide galactosyltransferase, CGT) knockout mice. The prediction that the phenotype...
6.
Baerwald K, Corbin J, Popko B
J Neurosci Res
. 2000 Jan;
59(2):160-9.
PMID: 10650874
The immune cytokine interferon-gamma (IFN-gamma) is believed to be a key agent in the pathogenesis of immune-mediated demyelinating disorders. We have examined the possibility that one effect of this cytokine...
7.
Popko B, Dupree J, Coetzee T, Suzuki K
Adv Exp Med Biol
. 2000 Jan;
468:237-44.
PMID: 10635033
The CGT enzyme is responsible for catalyzing the final step in GalC synthesis. The isolation of the CGT cDNA has allowed for the genetic analysis of galactolipid function by providing...
8.
Popko B
Glia
. 2000 Jan;
29(2):149-53.
PMID: 10625333
The precise alignment of myelin segments along the length of the axon is essential for the saltatory propagation of an electrical impulse. Furthermore, node of Ranvier formation and function are...
9.
Dupree J, Girault J, Popko B
J Cell Biol
. 1999 Dec;
147(6):1145-52.
PMID: 10601330
Mice incapable of synthesizing the abundant galactolipids of myelin exhibit disrupted paranodal axo-glial interactions in the central and peripheral nervous systems. Using these mutants, we have analyzed the role that...
10.
Gao X, Kemper A, Popko B
Neurochem Res
. 1999 Sep;
24(9):1181-8.
PMID: 10485590
Over the past two decades the techniques associated with the manipulation of the mouse genome have provided a powerful approach toward the better understanding of gene function. Conventional transgenic and...