B J Shenker
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Explore the profile of B J Shenker including associated specialties, affiliations and a list of published articles.
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55
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1089
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Recent Articles
1.
Blasi I, Korostoff J, Dhingra A, Reyes-Reveles J, Shenker B, Shahabuddin N, et al.
Mol Oral Microbiol
. 2015 Oct;
31(6):486-500.
PMID: 26452236
Porphyromonas gingivalis often subverts host cell autophagic processes for its own survival. Our previous studies document the association of the cargo sorting protein, melanoregulin (MREG), with its binding partner, the...
2.
Shenker B, Walker L, Zekavat A, Boesze-Battaglia K
Mol Oral Microbiol
. 2015 Aug;
31(1):33-42.
PMID: 26299277
The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) induces G2 arrest and apoptosis in lymphocytes and other cell types. We have shown that the active subunit, CdtB, exhibits phosphatidylinositol-3,4,5-triphosphate (PIP3) phosphatase...
3.
Lee W, Pankoski L, Zekavat A, Shenker B
Oral Microbiol Immunol
. 2004 Apr;
19(3):144-9.
PMID: 15107064
Oral spirochetes may contribute to the pathogenesis of a number of disorders including periodontal and periradicular diseases; however, the mechanism (s) by which these organisms act to cause disease is...
4.
Yamaguchi N, Kieba I, Korostoff J, Howard P, Shenker B, Lally E
Cell Microbiol
. 2001 Dec;
3(12):811-23.
PMID: 11736993
Subnanomolar concentrations (3 x 10(-10) M) of Actinobacillus actinomycetemcomitans leukotoxin (Ltx) trigger apoptosis of JY cells, as shown by a decrease in mitochondrial transmembrane potential (DeltaPsim), hyperproduction of reactive oxygen...
5.
Shenker B, Hoffmaster R, Zekavat A, Yamaguchi N, Lally E, Demuth D
J Immunol
. 2001 Jun;
167(1):435-41.
PMID: 11418680
We have previously shown that Actinobacillus actinomycetemcomitans produces an immunosuppressive factor that is encoded by the cdtB gene, which is homologous to a family of cytolethal distending toxins (Cdt) expressed...
6.
Shenker B, Guo T, Shapiro I
Environ Res
. 2000 Nov;
84(2):89-99.
PMID: 11068922
There is growing evidence that heavy metals, in general, and mercurial compounds, in particular, are toxic to the human immune system. In this regard, we have previously shown that both...
7.
Shenker B, Hoffmaster R, McKay T, Demuth D
J Immunol
. 2000 Aug;
165(5):2612-8.
PMID: 10946289
We have previously shown that Actinobacillus actinomycetemcomitans produces an immunosuppressive factor that is encoded by the cdtB gene, which is homologous to a family of cytolethal distending toxins (Cdt) expressed...
8.
Close A, Guo T, Shenker B
Toxicol Sci
. 1999 Jun;
49(1):68-77.
PMID: 10367343
Mercurials have been shown to cause apoptosis in human T cells. The objective of this study was to evaluate and compare the relative susceptibility of resting versus activated T cells...
9.
Shenker B, Guo T, O I, Shapiro I
Toxicol Appl Pharmacol
. 1999 May;
157(1):23-35.
PMID: 10329504
The objective of our study was to define the mechanism by which MeHgCl induces human T-cell apoptosis. We asked the question: does mercury disrupt the Deltapsim and induce a mitochondrial...
10.
Shenker B, McKay T, Datar S, Miller M, Chowhan R, Demuth D
J Immunol
. 1999 Apr;
162(8):4773-80.
PMID: 10202019
We have previously shown that Actinobacillus actinomycetecomitans produces an immunosuppressive factor (ISF) capable of impairing human lymphocyte function by perturbing cell cycle progression. We now report that ISF is the...