Ayaka Tatara
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Explore the profile of Ayaka Tatara including associated specialties, affiliations and a list of published articles.
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11
Citations
93
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Recent Articles
1.
Kitaichi M, Kato T, Oki H, Tatara A, Kawada T, Miyazaki K, et al.
Psychopharmacology (Berl)
. 2024 Jun;
241(11):2223-2239.
PMID: 38856765
Background: Current treatment of major depressive disorder is facing challenges, including a low remission rate, late onset of efficacy, and worsening severity due to comorbid symptoms such as psychosis and...
2.
Enomoto T, Tatara A, Goda M, Nishizato Y, Nishigori K, Kitamura A, et al.
J Pharmacol Exp Ther
. 2019 Oct;
371(3):692-702.
PMID: 31578257
In our drug discovery program, we identified a novel orally available and brain-penetrant phosphodiesterase (PDE) 1 inhibitor, 3-methyl-7-(tetrahydro-2-pyran-4-yl)-2-{[-4-(trifluoromethyl)cyclohexyl]-methoxy}imidazo[5,1-][1,2,4]triazin-4(3)-one (DSR-141562). In the present study, we characterized the preclinical profile of DSR-141562....
3.
Tatara A, Shimizu S, Masui A, Tamura M, Minamimoto S, Mizuguchi Y, et al.
Pharmacol Biochem Behav
. 2015 Sep;
138:14-9.
PMID: 26363311
Blonanserin is a new atypical antipsychotic drug that shows high affinities to dopamine D2 and 5-HT2 receptors; however, the mechanisms underlying its atypicality are not fully understood. In this study,...
4.
Ohno Y, Shimizu S, Tatara A, Imaoku T, Ishii T, Sasa M, et al.
PLoS One
. 2015 May;
10(5):e0123529.
PMID: 25970616
Genetic factors are thought to play a major role in the etiology of essential tremor (ET); however, few genetic changes that induce ET have been identified to date. In the...
5.
Shimizu S, Tatara A, Sato M, Sugiuchi T, Miyoshi S, Andatsu S, et al.
Prog Neuropsychopharmacol Biol Psychiatry
. 2013 Dec;
50:157-62.
PMID: 24368396
Dopamine D(3) receptors are highly expressed in the cerebellum; however, their pathophysiological functions are not fully understood. Here, we conducted microinjection studies to clarify the role of cerebellar D(3) receptors...
6.
Shimizu S, Mizuguchi Y, Tatara A, Kizu T, Andatsu S, Sobue A, et al.
Prog Neuropsychopharmacol Biol Psychiatry
. 2013 Jul;
46:86-91.
PMID: 23838274
We previously demonstrated that 5-HT stimulants, including selective serotonin reuptake inhibitors (SSRIs), potentiated antipsychotic-induced extrapyramidal symptoms (EPS) by stimulating 5-HT2A/2C, 5-HT3 and 5-HT6 receptors. Here, we studied the effects of...
7.
Ohno Y, Okano M, Masui A, Imaki J, Egawa M, Yoshihara C, et al.
Neuropharmacology
. 2012 May;
63(4):547-54.
PMID: 22580374
Spontaneously hypertensive rats (SHR) are widely used as a rat model of attention deficit/hyperactivity disorder (AD/HD). Here, we conducted neurochemical and behavioral studies in SHR to clarify the topographical alterations...
8.
Tatara A, Shimizu S, Shin N, Sato M, Sugiuchi T, Imaki J, et al.
Prog Neuropsychopharmacol Biol Psychiatry
. 2012 May;
38(2):252-9.
PMID: 22542492
Antipsychotic drugs are widely used not only for schizophrenia, but also for mood disorders such as bipolar disorder and depression. To evaluate the interactions between antipsychotics and drugs for mood...
9.
Ohno Y, Imaki J, Mae Y, Takahashi T, Tatara A
Neuropharmacology
. 2010 Sep;
60(2-3):201-8.
PMID: 20813116
Previous studies showed that 5-HT(1A) and 5-HT(2) receptors play an important role in controlling the extrapyramidal motor disorders. However, the functions of other 5-HT receptor subtypes remain elusive. To elucidate...
10.
Ohno Y, Okano M, Imaki J, Tatara A, Okumura T, Shimizu S
Pharmacol Biochem Behav
. 2010 May;
96(2):175-80.
PMID: 20460137
Blonanserin is a novel antipsychotic agent that preferentially interacts with dopamine D(2) and 5-HT(2A) receptors. To assess the atypical properties of blonanserin, we evaluated its propensity to induce extrapyramidal side...