Aya Ikkyu
Overview
Explore the profile of Aya Ikkyu including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
427
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Recent Articles
1.
Nakata S, Fujiyama T, Asano F, Komiya H, Hotta-Hirashima N, Juichi M, et al.
Sleep
. 2024 Dec;
48(2).
PMID: 39656684
Study Objectives: Sleep/wakefulness is regulated by intracellular signaling pathways composed of protein kinases such as salt-inducible kinase 3 (Sik3). Sik3-deficiency in neurons decreases nonrapid eye movement (NREM) sleep time and...
2.
Miyanishi K, Hotta-Hirashima N, Miyoshi C, Hayakawa S, Kakizaki M, Kanno S, et al.
Neurosci Res
. 2023 Nov;
202:8-19.
PMID: 38029860
Although sleep is tightly regulated by multiple neuronal circuits in the brain, nonneuronal cells such as glial cells have been increasingly recognized as crucial sleep regulators. Recent studies have shown...
3.
Kim S, Hotta-Hirashima N, Asano F, Kitazono T, Iwasaki K, Nakata S, et al.
Nature
. 2022 Dec;
612(7940):512-518.
PMID: 36477539
Progress has been made in the elucidation of sleep and wakefulness regulation at the neurocircuit level. However, the intracellular signalling pathways that regulate sleep and the neuron groups in which...
4.
Iwasaki K, Fujiyama T, Nakata S, Park M, Miyoshi C, Hotta-Hirashima N, et al.
J Neurosci
. 2021 Feb;
41(12):2733-2746.
PMID: 33558433
Sleep is regulated in a homeostatic manner. Sleep deprivation increases sleep need, which is compensated mainly by increased EEG δ power during non-rapid eye movement sleep (NREMS) and, to a...
5.
Ogawa Y, Miyoshi C, Obana N, Yajima K, Hotta-Hirashima N, Ikkyu A, et al.
Sci Rep
. 2020 Nov;
10(1):19554.
PMID: 33177599
Dysbiosis of the gut microbiota affects physiological processes, including brain functions, by altering the intestinal metabolism. Here we examined the effects of the gut microbiota on sleep/wake regulation. C57BL/6 male...
6.
Nakai A, Fujiyama T, Nagata N, Kashiwagi M, Ikkyu A, Takagi M, et al.
Genetics
. 2020 Sep;
216(3):753-764.
PMID: 32878901
The molecular mechanism regulating sleep largely remains to be elucidated. In humans, families that carry mutations in , which encodes the transcription factor AP-2β, self-reported sleep abnormalities such as short-sleep...
7.
Park M, Miyoshi C, Fujiyama T, Kakizaki M, Ikkyu A, Honda T, et al.
Sci Rep
. 2020 May;
10(1):8676.
PMID: 32457359
Although sleep is one of the most conserved behaviors, the intracellular mechanism regulating sleep/wakefulness remains unknown. We recently identified a protein kinase, SIK3, as a sleep-regulating molecule. Mice that lack...
8.
Kakizaki M, Tsuneoka Y, Takase K, Kim S, Choi J, Ikkyu A, et al.
iScience
. 2019 Sep;
20:1-13.
PMID: 31546102
Orexins are hypothalamic neuropeptides that regulate feeding, energy expenditure, and sleep. Although orexin-deficient mice are susceptible to obesity, little is known about the roles of the orexin receptors in long-term...
9.
Miyoshi C, Kim S, Ezaki T, Ikkyu A, Hotta-Hirashima N, Kanno S, et al.
Proc Natl Acad Sci U S A
. 2019 Jul;
116(32):16062-16067.
PMID: 31337678
The regulatory network of genes and molecules in sleep/wakefulness remains to be elucidated. Here we describe the methodology and workflow of the dominant screening of randomly mutagenized mice and discuss...
10.
Honda T, Fujiyama T, Miyoshi C, Ikkyu A, Hotta-Hirashima N, Kanno S, et al.
Proc Natl Acad Sci U S A
. 2018 Sep;
115(41):10458-10463.
PMID: 30254177
Sleep is an evolutionally conserved behavior from vertebrates to invertebrates. The molecular mechanisms that determine daily sleep amounts and the neuronal substrates for homeostatic sleep need remain unknown. Through a...