Awilda M Rosario
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Explore the profile of Awilda M Rosario including associated specialties, affiliations and a list of published articles.
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13
Citations
528
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Recent Articles
1.
Cockey S, McFarland K, Koller E, Brooks M, De La Cruz E, Cruz P, et al.
NPJ Parkinsons Dis
. 2021 Mar;
7(1):30.
PMID: 33741985
Parkinson's disease (PD) and related synucleinopathies are characterized by chronic neuroinflammation leading to the premise that anti-inflammatory therapies could ameliorate synucleinopathy and associated sequelae. To test this idea, we used...
2.
Deyts C, Clutter M, Pierce N, Chakrabarty P, Ladd T, Goddi A, et al.
Cell Rep
. 2019 May;
27(5):1345-1355.e6.
PMID: 31042463
Amyloid precursor protein (APP) and its metabolites play key roles in Alzheimer's disease (AD) pathophysiology. Whereas short amyloid-β (Aβ) peptides derived from APP are pathogenic, the APP holoprotein serves multiple...
3.
Chakrabarty P, Li A, Ladd T, Strickland M, Koller E, Burgess J, et al.
J Exp Med
. 2018 Aug;
215(9):2247-2264.
PMID: 30158114
There is considerable interest in harnessing innate immunity to treat Alzheimer's disease (AD). Here, we explore whether a decoy receptor strategy using the ectodomain of select TLRs has therapeutic potential...
4.
Prasad T, Zhu P, Verma A, Chakrabarty P, Rosario A, Golde T, et al.
Sci Rep
. 2017 Jun;
7(1):3222.
PMID: 28607377
Age-related macular degeneration (AMD) is a progressive retinal neurodegenerative disorder characterized by extracellular deposits known as drusen. A major constituent of drusen deposits are Alzheimer disease-associated amyloid β (Aβ) peptides....
5.
Leclerc J, Santiago-Moreno J, Dang A, Lampert A, Cruz P, Rosario A, et al.
J Cereb Blood Flow Metab
. 2016 Nov;
38(6):1032-1046.
PMID: 27864463
Following intracerebral hemorrhage (ICH), extracellular heme precipitates secondary brain injury, which results in irreversible brain damage and enduring neurological deficits. Hemopexin (Hpx) is an endogenous protein responsible for scavenging heme,...
6.
Rosario A, Cruz P, Ceballos-Diaz C, Strickland M, Siemienski Z, Pardo M, et al.
Mol Ther Methods Clin Dev
. 2016 Jun;
3:16026.
PMID: 27308302
Recombinant adeno-associated viruses (rAAV) have been widely used in gene therapy applications for central nervous system diseases. Though rAAV can efficiently target neurons and astrocytes in mouse brains, microglia, the...
7.
Bean L, Kumar A, Rani A, Guidi M, Rosario A, Cruz P, et al.
J Neurosci
. 2015 Dec;
35(49):16077-93.
PMID: 26658861
Significance Statement: Estradiol is neuroprotective, promotes synaptic plasticity in the hippocampus, and protects against cognitive decline associated with aging and neurodegenerative diseases. However, animal models and clinical studies indicate a...
8.
Ceballos-Diaz C, Rosario A, Park H, Chakrabarty P, Sacino A, Cruz P, et al.
Mol Neurodegener
. 2015 Jul;
10:25.
PMID: 26152284
Background: UBQLN2 mutations have recently been associated with familial forms of amyotrophic lateral sclerosis (ALS) and ALS-dementia. UBQLN2 encodes for ubiquilin-2, a member of the ubiquitin-like protein family which facilitates...
9.
Levites Y, ONuallain B, Puligedda R, Ondrejcak T, Adekar S, Chen C, et al.
J Neurosci
. 2015 Apr;
35(16):6265-76.
PMID: 25904780
Alzheimer's disease (AD) and familial Danish dementia (FDD) are degenerative neurological diseases characterized by amyloid pathology. Normal human sera contain IgG antibodies that specifically bind diverse preamyloid and amyloid proteins...
10.
Chakrabarty P, Li A, Ceballos-Diaz C, Eddy J, Funk C, Moore B, et al.
Neuron
. 2015 Jan;
85(3):519-33.
PMID: 25619653
Anti-inflammatory strategies are proposed to have beneficial effects in Alzheimer's disease. To explore how anti-inflammatory cytokine signaling affects Aβ pathology, we investigated the effects of adeno-associated virus (AAV2/1)-mediated expression of...