Auke P Verhaar
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Explore the profile of Auke P Verhaar including associated specialties, affiliations and a list of published articles.
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23
Citations
817
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Recent Articles
11.
Verhaar A, Hoekstra E, Tjon A, Utomo W, Deuring J, Bakker E, et al.
Sci Rep
. 2014 Jun;
4:5468.
PMID: 24968806
Space flight strongly moderates human immunity but is in general well tolerated. Elucidation of the mechanisms by which zero gravity interacts with human immunity may provide clues for developing rational...
12.
Verhaar A, Wildenberg M, Peppelenbosch M, Hommes D, van den Brink G
J Pharmacol Exp Ther
. 2014 May;
350(2):189-95.
PMID: 24833702
Miltefosine is an ether lipid that was initially developed for cancer treatment in the early 1980s. Miltefosine largely failed development for oncology, although it was approved for the topical treatment...
13.
Verhaar A, Wildenberg M, Te Velde A, Meijer S, Vos A, Duijvestein M, et al.
Inflamm Bowel Dis
. 2013 Jul;
19(9):1974-82.
PMID: 23811637
Background: The repertoire of immunomodulators that can be used for the treatment of inflammatory bowel disease is limited. The use of these drugs is further restricted by the occurrence of...
14.
Verhaar A, Wildenberg M, Duijvestein M, Vos A, Peppelenbosch M, Lowenberg M, et al.
J Immunol
. 2013 May;
190(12):6589-95.
PMID: 23690479
The glucocorticoid receptor is present in a TCR-associated complex, which includes the Src family tyrosine kinase Lck. Glucocorticoids rapidly dissociate this complex, resulting in the inhibition of canonical Lck-phospholipase C...
15.
Strisciuglio C, Duijvestein M, Verhaar A, Vos A, van den Brink G, Hommes D, et al.
J Crohns Colitis
. 2012 Sep;
7(7):534-41.
PMID: 22981596
Background And Aims: Dendritic cells (DC) are key players in intestinal immunity, as these cells can direct the immune response to either a tolerogenic or an immunogenic phenotype. In the...
16.
Wildenberg M, Vos A, Wolfkamp S, Duijvestein M, Verhaar A, Te Velde A, et al.
Gastroenterology
. 2012 Feb;
142(7):1493-503.e6.
PMID: 22370477
Background & Aims: Variants in the genes ATG16L1 and IRGM affect autophagy and are associated with the development of Crohn's disease. It is not clear how autophagy is linked to...
17.
Vos A, Wildenberg M, Arijs I, Duijvestein M, Verhaar A, De Hertogh G, et al.
Inflamm Bowel Dis
. 2011 Sep;
18(3):401-8.
PMID: 21936028
Background: Regulatory macrophages play an important role in wound healing and gut homeostasis and have antiinflammatory properties. Induction of this cell type (Mψ(ind) ) by the anti-tumor necrosis factor (TNF)...
18.
Strehl C, Gaber T, Lowenberg M, Hommes D, Verhaar A, Schellmann S, et al.
Arthritis Rheum
. 2011 Sep;
63(12):3779-88.
PMID: 21898343
Objective: Glucocorticoids (GCs) exert their antiinflammatory and immunosuppressive effects in humans primarily via the cytosolic GC receptor (cGR) but also via rapid, nongenomic mechanisms. Most likely, membrane-bound GRs (mGR) are...
19.
Duijvestein M, Molendijk I, Roelofs H, Vos A, Verhaar A, Reinders M, et al.
Cytotherapy
. 2011 Aug;
13(9):1066-73.
PMID: 21846292
Background And Aims: Mesenchymal stromal cells (MSC) have both multilineage differentiation capacity and immunosuppressive properties. Promising results with MSC administration have been obtained in experimental colitis. Clinical application of MSC...
20.
Vos A, Wildenberg M, Duijvestein M, Verhaar A, van den Brink G, Hommes D
Gastroenterology
. 2010 Oct;
140(1):221-30.
PMID: 20955706
Background & Aims: Anti-tumor necrosis factor (TNF)α antibodies are effective in treating patients with Crohn's disease whereas soluble TNFα receptors have not shown clinical efficacy; the mechanism that underlies these...