Auke B C Otten
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Explore the profile of Auke B C Otten including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
189
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Recent Articles
1.
Takashima S, Sun W, Otten A, Cai P, Peng S, Tong E, et al.
Cell Rep
. 2024 Feb;
43(3):113814.
PMID: 38402585
Alternative splicing (AS) of messenger RNAs occurs in ∼95% of multi-exon human genes and generates diverse RNA and protein isoforms. We investigated AS events associated with human epidermal differentiation, a...
2.
Otten A, Amarbayar O, Cai P, Cheng B, Qu K, Sun B
J Invest Dermatol
. 2023 Mar;
143(9):1825-1830.e6.
PMID: 36906126
No abstract available.
3.
Otten A, Kamps R, Lindsey P, Gerards M, Pendeville-Samain H, Muller M, et al.
Front Cell Dev Biol
. 2020 Jun;
8:381.
PMID: 32596237
High mitochondrial DNA (mtDNA) copy numbers are essential for oogenesis and embryogenesis and correlate with fertility of oocytes and viability of embryos. To understand the pathology and mechanisms associated with...
4.
Otten A, Sun B
J Invest Dermatol
. 2020 Mar;
140(4):723-728.e1.
PMID: 32200874
CRISPR and Cas proteins, often referred to as CRISPR/Cas, are the components of a bacterial genome editing system that can be used to perturb genes in cells and tissues. A...
5.
Cai P, Otten A, Cheng B, Ishii M, Zhang W, Huang B, et al.
Genome Res
. 2019 Dec;
30(1):22-34.
PMID: 31804951
Genome-wide association studies indicate that many disease susceptibility regions reside in non-protein-coding regions of the genome. Long noncoding RNAs (lncRNAs) are a major component of the noncoding genome, but their...
6.
Chen S, Ishii M, Cheng B, Otten A, Sun B
J Invest Dermatol
. 2019 Apr;
139(9):2039-2042.e2.
PMID: 30959041
No abstract available.
7.
Eijkenboom I, Sopacua M, Otten A, Gerrits M, Hoeijmakers J, Waxman S, et al.
Exp Neurol
. 2018 Oct;
311:257-264.
PMID: 30316835
Small-fiber neuropathy (SFN) patients experience a spectrum of sensory abnormalities, including attenuated responses to non-noxious temperatures in combination with a decreased density of the small-nerve fibers. Gain-of-function mutations in the...
8.
Otten A, Sallevelt S, Carling P, Dreesen J, Drusedau M, Spierts S, et al.
Hum Reprod
. 2018 Jun;
33(7):1331-1341.
PMID: 29850888
Study Question: Does germline selection (besides random genetic drift) play a role during the transmission of heteroplasmic pathogenic mitochondrial DNA (mtDNA) mutations in humans? Summary Answer: We conclude that inheritance...
9.
Otten A, Stassen A, Adriaens M, Gerards M, Dohmen R, Timmer A, et al.
Genetics
. 2016 Oct;
204(4):1423-1431.
PMID: 27770035
Of all pathogenic mitochondrial DNA (mtDNA) mutations in humans, ∼25% is de novo, although the occurrence in oocytes has never been directly assessed. We used next-generation sequencing to detect point...
10.
Otten A, Theunissen T, Derhaag J, Lambrichs E, Boesten I, Winandy M, et al.
Cell Rep
. 2016 Jul;
16(3):622-30.
PMID: 27373161
We studied the mtDNA bottleneck in zebrafish to elucidate size, timing, and variation in germline and non-germline cells. Mature zebrafish oocytes contain, on average, 19.0 × 10(6) mtDNA molecules with...