Audrey R Freischel
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Explore the profile of Audrey R Freischel including associated specialties, affiliations and a list of published articles.
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4
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45
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Recent Articles
1.
Gatenby R, Luddy K, Teer J, Berglund A, Freischel A, Carr R, et al.
Med Oncol
. 2024 May;
41(6):135.
PMID: 38704802
Somatic evolution selects cancer cell phenotypes that maximize survival and proliferation in dynamic environments. Although cancer cells are molecularly heterogeneous, we hypothesized convergent adaptive strategies to common host selection forces...
2.
Freischel A, Teer J, Luddy K, Cunningham J, Artzy-Randrup Y, Epstein T, et al.
Cancers (Basel)
. 2023 Jan;
15(1).
PMID: 36612014
We identify critical conserved and mutated genes through a theoretical model linking a gene’s fitness contribution to its observed mutational frequency in a clinical cohort. “Passenger” gene mutations do not...
3.
TFEB links MYC signaling to epigenetic control of myeloid differentiation and acute myeloid leukemia
Yun S, Vincelette N, Yu X, Watson G, Fernandez M, Yang C, et al.
Blood Cancer Discov
. 2021 Apr;
2(2):162-185.
PMID: 33860275
MYC oncoproteins regulate transcription of genes directing cell proliferation, metabolism and tumorigenesis. A variety of alterations drive expression in acute myeloid leukemia (AML) and enforced MYC expression in hematopoietic progenitors...
4.
Freischel A, Damaghi M, Cunningham J, Ibrahim-Hashim A, Gillies R, Gatenby R, et al.
Sci Rep
. 2021 Mar;
11(1):4908.
PMID: 33649456
Tumors are highly dynamic ecosystems in which diverse cancer cell subpopulations compete for space and resources. These complex, often non-linear interactions govern continuous spatial and temporal changes in the size...