Astrid Hammer
Overview
Explore the profile of Astrid Hammer including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
679
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0
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Recent Articles
1.
Jorgensen S, Lorentzen L, Hammer A, Hoefler G, Malle E, Chuang C, et al.
Redox Biol
. 2023 Jul;
64:102794.
PMID: 37402332
Continued oxidant production during chronic inflammation generates host tissue damage, with this being associated with pathologies including atherosclerosis. Atherosclerotic plaques contain modified proteins that may contribute to disease development, including...
2.
Wang Y, Hammer A, Hoefler G, Malle E, Hawkins C, Chuang C, et al.
Antioxidants (Basel)
. 2023 Feb;
12(2).
PMID: 36829979
Atherosclerosis is a chronic inflammatory disease and a leading cause of mortality. It is characterized by arterial wall plaques that contain high levels of cholesterol and other lipids and activated...
3.
Prasch J, Bernhart E, Reicher H, Kollroser M, Rechberger G, Koyani C, et al.
Int J Mol Sci
. 2020 Dec;
21(23).
PMID: 33287422
Sepsis is a major cause of mortality in critically ill patients and associated with cardiac dysfunction, a complication linked to immunological and metabolic aberrations. Cardiac neutrophil infiltration and subsequent release...
4.
Vanichkitrungruang S, Chuang C, Hawkins C, Hammer A, Hoefler G, Malle E, et al.
Free Radic Biol Med
. 2019 Apr;
136:118-134.
PMID: 30959171
Dysfunction of endothelial cells of the artery wall is an early event in cardiovascular disease and atherosclerosis. The cause(s) of this dysfunction are unresolved, but accumulating evidence suggests that oxidants...
5.
Nybo T, Dieterich S, Gamon L, Chuang C, Hammer A, Hoefler G, et al.
Redox Biol
. 2018 Nov;
20:496-513.
PMID: 30476874
Basement membranes are specialized extracellular matrices that underlie arterial wall endothelial cells, with laminin being a key structural and biologically-active component. Hypochlorous acid (HOCl), a potent oxidizing and chlorinating agent,...
6.
Bernhart E, Kogelnik N, Prasch J, Gottschalk B, Goeritzer M, Depaoli M, et al.
Redox Biol
. 2018 Feb;
15:441-451.
PMID: 29413957
Peripheral leukocytes induce blood-brain barrier (BBB) dysfunction through the release of cytotoxic mediators. These include hypochlorous acid (HOCl) that is formed via the myeloperoxidase-HO-chloride system of activated phagocytes. HOCl targets...
7.
Degendorfer G, Chuang C, Mariotti M, Hammer A, Hoefler G, Hagglund P, et al.
Free Radic Biol Med
. 2017 Dec;
115:219-231.
PMID: 29191462
Elastin is an abundant extracellular matrix protein in elastic tissues, including the lungs, skin and arteries, and comprises 30-57% of the aorta by dry mass. The monomeric precursor, tropoelastin (TE),...
8.
Koyani C, Kolesnik E, Wolkart G, Shrestha N, Scheruebel S, Trummer C, et al.
Biochem Pharmacol
. 2017 Sep;
145:64-80.
PMID: 28859968
Saxagliptin treatment has been associated with increased rate of hospitalization for heart failure in type 2 diabetic patients, though the underlying mechanism(s) remain elusive. To address this, we assessed the...
9.
Plastira I, Bernhart E, Goeritzer M, Reicher H, Kumble V, Kogelnik N, et al.
J Neuroinflammation
. 2016 Aug;
13(1):205.
PMID: 27565558
Background: Microglia, the immunocompetent cells of the CNS, rapidly respond to brain injury and disease by altering their morphology and phenotype to adopt an activated state. Microglia can exist broadly...
10.
Degendorfer G, Chuang C, Kawasaki H, Hammer A, Malle E, Yamakura F, et al.
Free Radic Biol Med
. 2016 Jul;
97:602-615.
PMID: 27396946
Fibronectin is a large dimeric glycoprotein present in both human plasma and in basement membranes. The latter are specialized extracellular matrices underlying endothelial cells in the artery wall. Peroxynitrous acid...