Astar Winoto
Overview
Explore the profile of Astar Winoto including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
1306
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0
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Recent Articles
1.
Zhao Z, Zhang G, Sun Y, Winoto A
Immun Inflamm Dis
. 2020 Jul;
8(3):468-479.
PMID: 32663380
Introduction: Priming of tumor-specific T cells is a key to antitumor immune response and inflammation, in turn, is crucial for proper T-cell activation. As antigen-presenting cells can activate T cells,...
2.
Banta K, Wang X, Das P, Winoto A
J Biol Chem
. 2018 Feb;
293(13):4724-4734.
PMID: 29414782
Apoptosis is mediated through the extrinsic or intrinsic pathway. Key regulators of the intrinsic apoptotic pathway are the family of B cell lymphoma 2 (Bcl-2) proteins. The activity of the...
3.
Schock S, Chandra N, Sun Y, Irie T, Kitagawa Y, Gotoh B, et al.
Cell Death Differ
. 2017 Jan;
24(4):615-625.
PMID: 28060376
Necroptosis is a form of necrotic cell death that requires the activity of the death domain-containing kinase RIP1 and its family member RIP3. Necroptosis occurs when RIP1 is deubiquitinated to...
4.
Kong N, Davis M, Chai L, Winoto A, Tjian R
PLoS Genet
. 2016 Feb;
12(2):e1005845.
PMID: 26900922
Hematopoietic stem cells are capable of self-renewal or differentiation along three main lineages: myeloid, erythroid, and lymphoid. One of the earliest lineage decisions for blood progenitor cells is whether to...
5.
Schock S, Young J, He T, Sun Y, Winoto A
PLoS One
. 2015 Apr;
10(4):e0124391.
PMID: 25874713
Myeloid cells, which include monocytes, macrophages, and granulocytes, are important innate immune cells, but the mechanism and downstream effect of their cell death on the immune system is not completely...
6.
Halkias J, Yen B, Taylor K, Reinhartz O, Winoto A, Robey E, et al.
Immunol Cell Biol
. 2015 Mar;
93(8):716-26.
PMID: 25744551
Humanized mice represent an important model to study the development and function of the human immune system. While it is known that mouse thymic stromal cells can support human T-cell...
7.
Burger M, Leung K, Bennett M, Winoto A
Elife
. 2014 Sep;
3.
PMID: 25182415
T cell self-tolerance is thought to involve peripheral tolerance and negative selection, involving apoptosis of autoreactive thymocytes. However, evidence supporting an essential role for negative selection is limited. Loss of...
8.
Burger M, Xue L, Sun Y, Kang C, Winoto A
Blood
. 2014 Apr;
123(26):4089-100.
PMID: 24735967
Cancer develops by a multistep process during which cells acquire characteristics that allow them to evade apoptosis and proliferate unchecked. Sequential acquisition of genetic alterations drives this process but also...
9.
Young J, He T, Reizis B, Winoto A
Cell Rep
. 2013 Jun;
3(6):1932-44.
PMID: 23727238
The relationship between dendritic cells (DCs) and commensal microflora in shaping systemic immune responses is not well understood. Here, we report that mice deficient for the Fas-associated death domain in...
10.
Halkias J, Melichar H, Taylor K, Ross J, Yen B, Cooper S, et al.
J Clin Invest
. 2013 Apr;
123(5):2131-42.
PMID: 23585474
The ordered migration of thymocytes from the cortex to the medulla is critical for the appropriate selection of the mature T cell repertoire. Most studies of thymocyte migration rely on...