Asok Kumar
Overview
Explore the profile of Asok Kumar including associated specialties, affiliations and a list of published articles.
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43
Citations
4500
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Recent Articles
1.
Berg M, Veeranna , Rosa C, Kumar A, Mohan P, Stavrides P, et al.
bioRxiv
. 2024 Jun;
PMID: 38854113
Accumulated levels of mutant huntingtin protein (mHTT) and its fragments are considered contributors to the pathogenesis of Huntington's disease (HD). Although lowering mHTT by stimulating autophagy has been considered a...
2.
Rao M, Darji S, Stavrides P, Goulbourne C, Kumar A, Yang D, et al.
Autophagy
. 2022 Sep;
19(4):1277-1292.
PMID: 36131358
How macroautophagy/autophagy influences neurofilament (NF) proteins in neurons, a frequent target in neurodegenerative diseases and injury, is not known. NFs in axons have exceptionally long half-lives enabling formation of large...
3.
Lee J, Wolfe D, Darji S, McBrayer M, Colacurcio D, Kumar A, et al.
J Mol Biol
. 2020 Feb;
432(8):2633-2650.
PMID: 32105735
Lysosomal dysfunction is considered pathogenic in Alzheimer disease (AD). Loss of presenilin-1 (PSEN1) function causing AD impedes acidification via defective vacuolar ATPase (vATPase) V0a1 subunit delivery to lysosomes. We report...
4.
Perez-Gonzalez R, Sahoo S, Gauthier S, Kim Y, Li M, Kumar A, et al.
Sci Rep
. 2019 Aug;
9(1):11104.
PMID: 31367000
Cystatin C (CysC) is implicated in neuroprotection and repair in the nervous system in response to diverse neurotoxic conditions. In addition to being secreted from cells in a soluble form,...
5.
Bordi M, Darji S, Sato Y, Mellen M, Berg M, Kumar A, et al.
Cell Death Dis
. 2019 Jul;
10(8):563.
PMID: 31332166
Down syndrome (DS), a complex genetic disorder caused by chromosome 21 trisomy, is associated with mitochondrial dysfunction leading to the accumulation of damaged mitochondria. Here we report that mitophagy, a...
6.
Jiang Y, Sato Y, Im E, Berg M, Bordi M, Darji S, et al.
J Neurosci
. 2019 May;
39(27):5255-5268.
PMID: 31043483
Lysosomal failure underlies pathogenesis of numerous congenital neurodegenerative disorders and is an early and progressive feature of Alzheimer's disease (AD) pathogenesis. Here, we report that lysosomal dysfunction in Down ayndrome...
7.
Yuan A, Veeranna , Sershen H, Basavarajappa B, Smiley J, Hashim A, et al.
Transl Psychiatry
. 2018 Aug;
8(1):167.
PMID: 30143609
Neurofilament (NFL) proteins have recently been found to play unique roles in synapses. NFL is known to interact with the GluN1 subunit of N-methyl-D-aspartic acid (NMDAR) and be reduced in...
8.
Vishwakarma A, Singh T, Rungsung S, Kumar T, Kandasamy A, Parida S, et al.
Cardiovasc Toxicol
. 2018 Jan;
18(4):312-328.
PMID: 29353381
The present study was undertaken to evaluate the effect of kaempferol in isoprenaline (ISP)-induced myocardial injury in rats. ISP was administered subcutaneously for two subsequent days to induce myocardial injury....
9.
Gowthaman V, Singh S, Dhama K, Desingu P, Kumar A, Singh Malik Y, et al.
Virusdisease
. 2017 May;
27(3):315-318.
PMID: 28466046
Newcastle disease virus (NDV) infects at least 241 species of pet and free-living birds in addition to domesticated avian species. Wild, feral and domesticated birds are recognized reservoirs of NDV,...
10.
Yang D, Stavrides P, Kumar A, Jiang Y, Mohan P, Ohno M, et al.
Hum Mol Genet
. 2017 Jan;
26(5):843-859.
PMID: 28062666
2-hydroxypropyl-β-cyclodextrin (CYCLO), a modifier of cholesterol efflux from cellular membrane and endo-lysosomal compartments, reduces lysosomal lipid accumulations and has therapeutic effects in animal models of Niemann-Pick disease type C and...