Asker Y Khapchaev
Overview
Explore the profile of Asker Y Khapchaev including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
10
Citations
43
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Sonin D, Medved M, Khapchaev A, Sidorova M, Palkeeva M, Kazakova O, et al.
Curr Issues Mol Biol
. 2025 Jan;
47(1).
PMID: 39852148
Myocardial ischemia-reperfusion injury increases myocardial microvascular permeability, leading to enhanced microvascular filtration and interstitial fluid accumulation that is associated with greater microvascular obstruction and inadequate myocardial perfusion. A burst of...
2.
Khapchaev A, Vorotnikov A, Antonova O, Samsonov M, Shestakova E, Sklyanik I, et al.
Biomedicines
. 2024 Feb;
12(2).
PMID: 38397940
Saturated free fatty acids are thought to play a critical role in metabolic disorders associated with obesity, insulin resistance, type 2 diabetes (T2D), and their vascular complications via effects on...
3.
Khapchaev A, Antonova O, Kazakova O, Samsonov M, Vorotnikov A, Shirinsky V
Biochemistry (Mosc)
. 2023 Sep;
88(8):1126-1138.
PMID: 37758312
Hyperglycemia is a hallmark of type 2 diabetes implicated in vascular endothelial dysfunction and cardiovascular complications. Many in vitro studies identified endothelial apoptosis as an early outcome of experimentally modeled...
4.
Vorotnikov A, Khapchaev A, Nickashin A, Shirinsky V
Biomedicines
. 2022 Dec;
10(12).
PMID: 36551937
Angiopathy is a common complication of diabetes mellitus. Vascular endothelium is among the first targets to experience blood-borne metabolic alterations, such as hyperglycemia and hyperlipidemia, the hallmarks of type 2...
5.
Samsonov M, Podkuychenko N, Khapchaev A, Efremov E, Yanushevskaya E, Vlasik T, et al.
Int J Mol Sci
. 2022 Jan;
23(1).
PMID: 35008640
Hyperlipidemia manifested by high blood levels of free fatty acids (FFA) and lipoprotein triglycerides is critical for the progression of type 2 diabetes (T2D) and its cardiovascular complications via vascular...
6.
Khapchaev A, Watterson D, Shirinsky V
Biochim Biophys Acta Mol Cell Res
. 2021 Jul;
1868(11):119104.
PMID: 34302892
Background: Myosin light chain kinase (MLCK) is a Ca-calmodulin-dependent enzyme dedicated to phosphorylate and activate myosin II to provide force for various motile processes. In smooth muscle cells and many...
7.
Kazakova O, Khapchaev A, Shirinsky V
Biochimie
. 2019 Nov;
168:83-91.
PMID: 31668993
Myosin activation contributes to the contractile forces that induce disturbances in the vascular endothelial integrity and promote protein-rich edema of the underlying tissues. Myosin light chain kinase (MLCK) and Rho-associated...
8.
Poluektov Y, Petrushanko I, Undrovinas N, Lakunina V, Khapchaev A, Kapelko V, et al.
Sci Rep
. 2019 Mar;
9(1):4872.
PMID: 30890744
Severe hypoxia leads to decline in cardiac contractility and induces arrhythmic events in part due to oxidative damage to cardiomyocyte proteins including ion transporters. This results in compromised handling of...
9.
Samsonov M, Khapchaev A, Vorotnikov A, Vlasik T, Yanushevskaya E, Sidorova M, et al.
Oxid Med Cell Longev
. 2017 Nov;
2017:1625130.
PMID: 29098058
Background: Malondialdehyde (MDA), glyoxal (GO), and methylglyoxal (MGO) levels increase in atherosclerosis and diabetes patients. Recent reports demonstrate that GO and MGO cause vascular endothelial barrier dysfunction whereas no evidence...
10.
Kapelko V, Lakomkin V, Abramov A, Lukoshkova E, Undrovinas N, Khapchaev A, et al.
Oxid Med Cell Longev
. 2017 Apr;
2017:9456163.
PMID: 28421129
. Nitric oxide can successfully compete with oxygen for sites of electron-transport chain in conditions of myocardial hypoxia. These features may prevent excessive oxidative stress occurring in cardiomyocytes during sudden...