Ashley C Humphries
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Explore the profile of Ashley C Humphries including associated specialties, affiliations and a list of published articles.
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11
Citations
206
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Recent Articles
1.
Butler J, Brown M, Prokocimer P, Humphries A, Pope S, Wright O, et al.
ESC Heart Fail
. 2024 Sep;
PMID: 39294891
Heart failure (HF) creates a considerable clinical, humanistic and economic burden on patients and caregivers as well as on healthcare systems. To attenuate the significant burden of HF, there is...
2.
Humphries A, Molina-Pelayo C, Sil P, Hazelett C, Devenport D, Mlodzik M
PLoS Genet
. 2023 Jul;
19(7):e1010849.
PMID: 37463168
Epithelial tissues can be polarized along two axes: in addition to apical-basal polarity they are often also polarized within the plane of the epithelium, known as planar cell polarity (PCP)....
3.
Bashorum L, McCaughey G, Evans O, Humphries A, Perry R, MacCulloch A
Orphanet J Rare Dis
. 2022 Jul;
17(1):266.
PMID: 35840992
Background: Fabry Disease (FD) is a rare X-linked metabolic lysosomal disorder. FD has a broad range of symptoms which vary markedly between patients. The heterogenous nature of the disease makes...
4.
Humphries A, Narang S, Mlodzik M
Elife
. 2020 Apr;
9.
PMID: 32234212
Planar cell polarity (PCP) and neural tube defects (NTDs) are linked, with a subset of NTD patients found to harbor mutations in PCP genes, but there is limited data on...
5.
Dimchev G, Amiri B, Humphries A, Schaks M, Dimchev V, Stradal T, et al.
J Cell Sci
. 2020 Feb;
133(7).
PMID: 32094266
Efficient migration on adhesive surfaces involves the protrusion of lamellipodial actin networks and their subsequent stabilization by nascent adhesions. The actin-binding protein lamellipodin (Lpd) is thought to play a critical...
6.
Bala Tannan N, Collu G, Humphries A, Serysheva E, Weber U, Mlodzik M
PLoS Genet
. 2018 Jan;
14(1):e1007153.
PMID: 29309414
AKAP200 is a Drosophila melanogaster member of the "A Kinase Associated Protein" family of scaffolding proteins, known for their role in the spatial and temporal regulation of Protein Kinase A...
7.
Snetkov X, Weisswange I, Pfanzelter J, Humphries A, Way M
Nat Microbiol
. 2016 Sep;
1(10):16141.
PMID: 27670116
During its egress, vaccinia virus transiently recruits AP-2 and clathrin after fusion with the plasma membrane. This recruitment polarizes the viral protein A36 beneath the virus, enhancing actin polymerization and...
8.
Humphries A, Donnelly S, Way M
J Cell Sci
. 2013 Nov;
127(Pt 3):673-85.
PMID: 24284073
Vaccinia virus enhances its cell-to-cell spread by inducing Arp2/3-dependent actin polymerisation. This process is initiated by Src- and Abl-mediated phosphorylation of the viral transmembrane protein A36, leading to recruitment of...
9.
Humphries A, Way M
Nat Rev Microbiol
. 2013 Sep;
11(8):551-60.
PMID: 24020073
The role of clathrin in pathogen entry has received much attention and has highlighted the adaptability of clathrin during internalization. Recent studies have now uncovered additional roles for clathrin and...
10.
Humphries A, Dodding M, Barry D, Collinson L, Durkin C, Way M
Cell Host Microbe
. 2012 Sep;
12(3):346-59.
PMID: 22980331
During their egress, newly assembled vaccinia virus particles fuse with the plasma membrane and enhance their spread by inducing Arp2/3-dependent actin polymerization. Investigating the events surrounding vaccinia virus fusion, we...