Ashfaq M Sheikh
Overview
Explore the profile of Ashfaq M Sheikh including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
787
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Recent Articles
1.
Cao F, Yin A, Wen G, Sheikh A, Tauqeer Z, Malik M, et al.
J Neuroinflammation
. 2016 May;
13(1):106.
PMID: 27178190
No abstract available.
2.
Cao F, Yin A, Wen G, Sheikh A, Tauqeer Z, Malik M, et al.
J Neuroinflammation
. 2012 Sep;
9:223.
PMID: 22999633
Background: Autism is a neurodevelopmental disorder characterized by impairments in social interaction, verbal communication and repetitive behaviors. To date the etiology of this disorder is poorly understood. Studies suggest that...
3.
Wei H, Dobkin C, Sheikh A, Malik M, Brown W, Li X
PLoS One
. 2012 May;
7(5):e36981.
PMID: 22615862
Although the pathogenic mechanisms that underlie autism are not well understood, there is evidence showing that metabotropic and ionotropic glutamate receptors are hyper-stimulated and the GABAergic system is hypo-stimulated in...
4.
Yang K, Cao F, Sheikh A, Malik M, Wen G, Wei H, et al.
Brain Struct Funct
. 2012 May;
218(3):669-82.
PMID: 22555958
The Ras/Raf/ERK1/2 signaling pathway controls many cellular responses such as cell proliferation, migration, differentiation, and death. In the nervous system, emerging evidence also points to a death-promoting role for ERK1/2...
5.
Wei H, Chadman K, McCloskey D, Sheikh A, Malik M, Brown W, et al.
Biochim Biophys Acta
. 2012 Feb;
1822(6):831-42.
PMID: 22326556
Abnormal immune responses have been reported to be associated with autism. A number of studies showed that cytokines were increased in the blood, brain, and cerebrospinal fluid of autistic subjects....
6.
Malik M, Tauqeer Z, Sheikh A, Wen G, Nagori A, Yang K, et al.
Mediators Inflamm
. 2011 Nov;
2011:785265.
PMID: 22046080
Autism is a neurodevelopmental disorder characterized by problems in communication, social skills, and repetitive behavior. Recent studies suggest that apoptotic and inflammatory mechanisms may contribute to the pathogenesis of this...
7.
Wei H, Malik M, Sheikh A, Merz G, Brown W, Li X
Am J Pathol
. 2011 Jun;
179(1):66-74.
PMID: 21703394
Recent studies suggest that one of the major pathways to the pathogenesis of autism is reduced cell migration. Focal adhesion kinase (FAK) has an important role in neural migration, dendritic...
8.
Wei H, Zou H, Sheikh A, Malik M, Dobkin C, Brown W, et al.
J Neuroinflammation
. 2011 May;
8:52.
PMID: 21595886
Background: Although the cellular mechanisms responsible for the pathogenesis of autism are not understood, a growing number of studies have suggested that localized inflammation of the central nervous system (CNS)...
9.
Malik M, Fenko M, Sheikh A, Wen G, Li X
Neurochem Res
. 2011 Jan;
36(5):754-60.
PMID: 21267651
Cathepsin D is the lysosomal protease abundantly expressed in the brain. It plays an important role in the regulation of cellular apoptosis. In addition, cathepsin D has been shown to...
10.
Sheikh A, Malik M, Wen G, Chauhan A, Chauhan V, Gong C, et al.
J Neurosci Res
. 2010 Jul;
88(12):2641-7.
PMID: 20648653
Although the pathogenesis of autism is not understood, emerging evidence points to apoptotic mechanisms being involved in this disorder. However, it is not known whether apoptosis signaling is deregulated in...