Aseem Chaphalkar
Overview
Explore the profile of Aseem Chaphalkar including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
19
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Recent Articles
1.
Sadat A, Tiwari S, Sunidhi S, Chaphalkar A, Kochar M, Ali M, et al.
Proc Natl Acad Sci U S A
. 2022 Apr;
119(18):e2118465119.
PMID: 35486698
The GroEL/ES chaperonin cavity surface charge properties, especially the negative charges, play an important role in its capacity to assist intracavity protein folding. Remarkably, the larger fraction of GroEL/ES negative...
2.
Verma K, Verma M, Chaphalkar A, Chakraborty K
Fac Rev
. 2021 Oct;
10:72.
PMID: 34632458
Maintenance of a functional proteome is achieved through the mechanism of proteostasis that involves precise coordination between molecular machineries assisting a protein from its conception to demise. Although each organelle...
3.
Sadat A, Tiwari S, Verma K, Ray A, Ali M, Upadhyay V, et al.
J Mol Biol
. 2020 Aug;
432(20):5649-5664.
PMID: 32835659
The folding landscape of proteins can change during evolution with the accumulation of mutations that may introduce entropic or enthalpic barriers in the protein folding pathway, making it a possible...
4.
Verma K, Saxena K, Donaka R, Chaphalkar A, Rai M, Shukla A, et al.
Nat Commun
. 2020 Jun;
11(1):2926.
PMID: 32522991
Metabolic changes alter the cellular milieu; can this also change intracellular protein folding? Since proteostasis can modulate mutational buffering, if change in metabolism has the ability to change protein folding,...