Arvind Govindarajan
Overview
Explore the profile of Arvind Govindarajan including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
2151
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0
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Recent Articles
1.
Dolan B, Duron S, Campbell D, Vollrath B, Rao B, Ko H, et al.
Proc Natl Acad Sci U S A
. 2013 Mar;
110(14):5671-6.
PMID: 23509247
Fragile X syndrome (FXS) is the most common inherited form of autism and intellectual disability and is caused by the silencing of a single gene, fragile X mental retardation 1...
2.
Liu X, Ramirez S, Pang P, Puryear C, Govindarajan A, Deisseroth K, et al.
Nature
. 2012 Mar;
484(7394):381-5.
PMID: 22441246
A specific memory is thought to be encoded by a sparse population of neurons. These neurons can be tagged during learning for subsequent identification and manipulation. Moreover, their ablation or...
3.
Govindarajan A, Israely I, Huang S, Tonegawa S
Neuron
. 2011 Jan;
69(1):132-46.
PMID: 21220104
The late-phase of long-term potentiation (L-LTP), the cellular correlate of long-term memory, induced at some synapses facilitates L-LTP expression at other synapses receiving stimulation too weak to induce L-LTP by...
4.
Slutsky I, Abumaria N, Wu L, Huang C, Zhang L, Li B, et al.
Neuron
. 2010 Feb;
65(2):165-77.
PMID: 20152124
Learning and memory are fundamental brain functions affected by dietary and environmental factors. Here, we show that increasing brain magnesium using a newly developed magnesium compound (magnesium-L-threonate, MgT) leads to...
5.
Chen D, Steele A, Hutter G, Bruno J, Govindarajan A, Easlon E, et al.
Exp Gerontol
. 2008 Sep;
43(12):1086-93.
PMID: 18799131
A central focus of aging research is to determine how calorie restriction (CR) extends lifespan and delays diseases of aging. SIRT1, the mammalian ortholog of Sir2 in yeast, is a...
6.
Govindarajan A, Rao B, Nair D, Trinh M, Mawjee N, Tonegawa S, et al.
Proc Natl Acad Sci U S A
. 2006 Aug;
103(35):13208-13.
PMID: 16924103
Although neurotrophins have been postulated to have antidepressant properties, their effect on anxiety is not clear. We find that transgenic overexpression of the neurotrophin BDNF has an unexpected facilitatory effect...
7.
Govindarajan A, Kelleher R, Tonegawa S
Nat Rev Neurosci
. 2006 Jun;
7(7):575-83.
PMID: 16791146
Long-term memory and its putative synaptic correlates the late phases of both long-term potentiation and long-term depression require enhanced protein synthesis. On the basis of recent data on translation-dependent synaptic...
8.
Kelleher 3rd R, Govindarajan A, Tonegawa S
Neuron
. 2004 Sep;
44(1):59-73.
PMID: 15450160
Memory and synaptic plasticity exhibit distinct temporal phases, with long-lasting forms distinguished by their dependence on macromolecular synthesis. Prevailing models for the molecular mechanisms underlying long-lasting synaptic plasticity have largely...
9.
Kelleher 3rd R, Govindarajan A, Jung H, Kang H, Tonegawa S
Cell
. 2004 Mar;
116(3):467-79.
PMID: 15016380
Enduring forms of synaptic plasticity and memory require new protein synthesis, but little is known about the underlying regulatory mechanisms. Here, we investigate the role of MAPK signaling in these...