Arnaud L Lalive
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Explore the profile of Arnaud L Lalive including associated specialties, affiliations and a list of published articles.
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16
Citations
533
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Recent Articles
1.
Mondoloni S, Molina P, Lecca S, Wu C, Michel L, Osypenko D, et al.
Science
. 2024 Sep;
385(6713):1081-1086.
PMID: 39236168
Negative emotional contagion-witnessing others in distress-affects an individual's emotional responsivity. However, whether it shapes coping strategies when facing future threats remains unknown. We found that mice that briefly observe a...
2.
Monsorno K, Ginggen K, Ivanov A, Buckinx A, Lalive A, Tchenio A, et al.
Nat Commun
. 2023 Sep;
14(1):5749.
PMID: 37717033
Microglia, the innate immune cells of the central nervous system, actively participate in brain development by supporting neuronal maturation and refining synaptic connections. These cells are emerging as highly metabolically...
3.
Congiu M, Mondoloni S, Zouridis I, Schmors L, Lecca S, Lalive A, et al.
Mol Psychiatry
. 2023 Jul;
28(12):5118-5127.
PMID: 37414924
The brain's ability to associate threats with external stimuli is vital to execute essential behaviours including avoidance. Disruption of this process contributes instead to the emergence of pathological traits which...
4.
Lalive A, Congiu M, Lewis C, Groos D, Clerke J, Tchenio A, et al.
Curr Biol
. 2022 Mar;
32(8):1829-1836.e4.
PMID: 35259343
The lateral habenula (LHb) supports learning processes enabling the prediction of upcoming rewards. While reward-related stimuli decrease the activity of LHb neurons, whether this anchors on synaptic inhibition to guide...
5.
Lalive A, Nuno-Perez A, Tchenio A, Mameli M
Eur J Neurosci
. 2021 Dec;
55(2):377-387.
PMID: 34963191
Animals can cope with isolated stressful situations without enduring long-term consequences. However, when exposure to stressors becomes recurrent, behavioural symptoms of anxiety and depression can emerge. Yet, the neuronal mechanisms...
6.
Pimpinella D, Mastrorilli V, Giorgi C, Coemans S, Lecca S, Lalive A, et al.
Elife
. 2021 Oct;
10.
PMID: 34696824
Acetylcholine (ACh), released in the hippocampus from fibers originating in the medial septum/diagonal band of Broca (MSDB) complex, is crucial for learning and memory. The CA2 region of the hippocampus...
7.
Nuno-Perez A, Trusel M, Lalive A, Congiu M, Gastaldo D, Tchenio A, et al.
Neuron
. 2021 Feb;
109(6):947-956.e5.
PMID: 33535028
Weighing alternatives during reward pursuit is a vital cognitive computation that, when disrupted by stress, yields aspects of neuropsychiatric disorders. To examine the neural mechanisms underlying these phenomena, we employed...
8.
Valentinova K, Tchenio A, Trusel M, Clerke J, Lalive A, Tzanoulinou S, et al.
Nat Neurosci
. 2019 Jun;
22(7):1053-1056.
PMID: 31209376
The lateral habenula encodes aversive stimuli contributing to negative emotional states during drug withdrawal. Here we report that morphine withdrawal in mice leads to microglia adaptations and diminishes glutamatergic transmission...
9.
Punishment-Predictive Cues Guide Avoidance through Potentiation of Hypothalamus-to-Habenula Synapses
Trusel M, Nuno-Perez A, Lecca S, Harada H, Lalive A, Congiu M, et al.
Neuron
. 2019 Feb;
102(1):120-127.e4.
PMID: 30765165
Throughout life, individuals learn to predict a punishment via its association with sensory stimuli. This process ultimately prompts goal-directed actions to prevent the danger, a behavior defined as avoidance. Neurons...
10.
Lalive A, Lien A, Roseberry T, Donahue C, Kreitzer A
Elife
. 2018 Oct;
7.
PMID: 30295606
Reinforcement has long been thought to require striatal synaptic plasticity. Indeed, direct striatal manipulations such as self-stimulation of direct-pathway projection neurons (dMSNs) are sufficient to induce reinforcement within minutes. However,...