Arjan J van Adrichem
Overview
Explore the profile of Arjan J van Adrichem including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
869
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0
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Recent Articles
1.
Deben D, Creemers R, van Adrichem A, Drent R, Merry A, Leers M, et al.
Sci Rep
. 2022 Sep;
12(1):15806.
PMID: 36138194
The thiopurine derivatives azathioprine (AZA), mercaptopurine (MP) and tioguanine (TG) remain standard treatment of inflammatory bowel disease (IBD). The immune suppressive effect of thiopurines is primarily based on blocking the...
2.
Deben D, van Adrichem A, Drent R, Puts S, Pelzer K, van Bodegraven A, et al.
Cytometry A
. 2021 Oct;
101(2):167-176.
PMID: 34595833
Thiopurine derivatives, such as azathioprine and mercaptopurine, are standard conventional treatment options in inflammatory bowel disease (IBD). Unfortunately, approximately half of patients discontinue thiopurine therapy within 2 years. To improve...
3.
Martens R, van Adrichem A, Mattheij N, Brouwer C, van Twist D, Broerse J, et al.
Clin Chem Lab Med
. 2021 Feb;
59(4):783-793.
PMID: 33554540
Objectives: COVID-19 is an ongoing global pandemic. There is an urgent need for identification and understanding of clinical and laboratory parameters related to progression towards a severe and fatal form...
4.
Parri E, Kuusanmaki H, van Adrichem A, Kaustio M, Wennerberg K
PLoS One
. 2020 Apr;
15(3):e0230819.
PMID: 32231398
STAT3 mediates signalling downstream of cytokine and growth factor receptors where it acts as a transcription factor for its target genes, including oncogenes and cell survival regulating genes. STAT3 has...
5.
Harma H, Tong-Ochoa N, van Adrichem A, Jelesarov I, Wennerberg K, Kopra K
Chem Commun (Camb)
. 2018 Mar;
54(23):2910-2913.
PMID: 29498735
Post-translational modification (PTM) of proteins plays essential regulatory roles in a variety of pathological conditions. Reliable and practical assays are required to accelerate the discovery of inhibitors and activators for...
6.
Tang J, Tanoli Z, Ravikumar B, Alam Z, Rebane A, Vaha-Koskela M, et al.
Cell Chem Biol
. 2017 Dec;
25(2):224-229.e2.
PMID: 29276046
Knowledge of the full target space of bioactive substances, approved and investigational drugs as well as chemical probes, provides important insights into therapeutic potential and possible adverse effects. The existing...
7.
Kuusanmaki H, Dufva O, Parri E, van Adrichem A, Rajala H, Majumder M, et al.
Oncotarget
. 2017 Dec;
8(57):97516-97527.
PMID: 29228628
Constitutive JAK/STAT3 signaling contributes to disease progression in many lymphoproliferative disorders. Recent genetic analyses have revealed gain-of-function mutations in lymphoid cancers leading to hyperactivation of STAT3, which may represent a...
8.
Kopra K, van Adrichem A, Salo-Ahen O, Peltonen J, Wennerberg K, Harma H
Anal Chem
. 2017 Mar;
89(8):4508-4516.
PMID: 28318223
Ras GTPases act as "molecular switches", alternating between inactive GDP-bound and active GTP-bound conformation. Ras-oncogenes were discovered over three decades ago, but there are still no effective therapies for Ras-driven...
9.
van Adrichem A, Wennerberg K
FEBS Lett
. 2015 Nov;
589(24 Pt B):3859-65.
PMID: 26602080
Male germ cell Rac GTPase-activating protein (MgcRacGAP) is a core regulator of cytokinesis. Furthermore, it appears to be involved in human oncogenesis through cytokinesis-independent mechanisms and has been reported to...
10.
van Adrichem A, Fagerholm A, Turunen L, Lehto A, Saarela J, Koskinen A, et al.
Comb Chem High Throughput Screen
. 2014 Dec;
18(1):3-17.
PMID: 25479424
The Rho family of Ras superfamily small GTPases regulates a broad range of biological processes such as migration, differentiation, cell growth and cell survival. Therefore, the availability of small molecule...