Arig Ibrahim-Hashim
Overview
Explore the profile of Arig Ibrahim-Hashim including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
1772
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Recent Articles
11.
Ibrahim-Hashim A, Luddy K, Abrahams D, Enriquez-Navas P, Damgaci S, Yao J, et al.
Br J Cancer
. 2020 Oct;
124(2):455-465.
PMID: 33024265
Background: Cancer progression is governed by evolutionary dynamics in both the tumour population and its host. Since cancers die with the host, each new population of cancer cells must reinvent...
12.
Damgaci S, Enriquez-Navas P, Pilon-Thomas S, Guvenis A, Gillies R, Ibrahim-Hashim A
Eur J Clin Nutr
. 2020 Sep;
74(Suppl 1):3-6.
PMID: 32873950
No abstract available.
13.
Wu H, Estrella V, Beatty M, Abrahams D, El-Kenawi A, Russell S, et al.
Nat Commun
. 2020 Aug;
11(1):4113.
PMID: 32807791
The acidic pH of tumors profoundly inhibits effector functions of activated CD8 + T-cells. We hypothesize that this is a physiological process in immune regulation, and that it occurs within...
14.
El-Kenawi A, Gatenbee C, Robertson-Tessi M, Bravo R, Dhillon J, Balagurunathan Y, et al.
Br J Cancer
. 2020 Jan;
122(7):1118.
PMID: 31937927
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
15.
El-Kenawi A, Gatenbee C, Robertson-Tessi M, Bravo R, Dhillon J, Balagurunathan Y, et al.
Br J Cancer
. 2019 Aug;
121(7):556-566.
PMID: 31417189
Background: Tumours rapidly ferment glucose to lactic acid even in the presence of oxygen, and coupling high glycolysis with poor perfusion leads to extracellular acidification. We hypothesise that acidity, independent...
16.
Ibrahim-Hashim A, Estrella V
Cancer Metastasis Rev
. 2019 Feb;
38(1-2):149-155.
PMID: 30806853
The extracellular pH of solid tumors is unequivocally acidic due to a combination of high rates of lactic acid production (a consequence of fermentative glycolytic metabolism) and poor perfusion. This...
17.
Walton Z, Patel C, Brooks R, Yu Y, Ibrahim-Hashim A, Riddle M, et al.
Cell
. 2018 Jun;
174(1):72-87.e32.
PMID: 29861175
Recent reports indicate that hypoxia influences the circadian clock through the transcriptional activities of hypoxia-inducible factors (HIFs) at clock genes. Unexpectedly, we uncover a profound disruption of the circadian clock...
18.
Damgaci S, Ibrahim-Hashim A, Enriquez-Navas P, Pilon-Thomas S, Guvenis A, Gillies R
Immunology
. 2018 Feb;
154(3):354-362.
PMID: 29485185
Due to imbalances between vascularity and cellular growth patterns, the tumour microenvironment harbours multiple metabolic stressors including hypoxia and acidosis, which have significant influences on remodelling both tumour and peritumoral...
19.
Ibrahim-Hashim A, Abrahams D, Enriquez-Navas P, Luddy K, Gatenby R, Gillies R
Cancer Med
. 2017 May;
6(7):1720-1729.
PMID: 28556628
Neutralizing tumor external acidity with oral buffers has proven effective for the prevention and inhibition of metastasis in several cancer mouse models. Solid tumors are highly acidic as a result...
20.
Ibrahim-Hashim A, Robertson-Tessi M, Enriquez-Navas P, Damaghi M, Balagurunathan Y, Wojtkowiak J, et al.
Cancer Res
. 2017 Mar;
77(9):2242-2254.
PMID: 28249898
Ongoing intratumoral evolution is apparent in molecular variations among cancer cells from different regions of the same tumor, but genetic data alone provide little insight into environmental selection forces and...